Imprinting and Recalling Cortical Ensembles

Details

• Alternative Title:
  Science
• Personal Author:
  Carrillo-Reid, Luis ; Yang, Weijian ; Bando, Yuki ; Peterka, Darcy S. ; Yuste, Rafael
• Description:
  Neuronal ensembles are coactive groups of neurons that may represent building blocks of cortical circuits. These ensembles could be formed by Hebbian plasticity, whereby synapses between coactive neurons are strengthened. Here we report that repetitive activation with two-photon optogenetics of neuronal populations from ensembles in the visual cortex of awake mice builds neuronal ensembles that recur spontaneously after being imprinted and do not disrupt preexisting ones. Moreover, imprinted ensembles can be recalled by single- cell stimulation and remain coactive on consecutive days. Our results demonstrate the persistent reconfiguration of cortical circuits by two-photon optogenetics into neuronal ensembles that can perform pattern completion.
• Subjects:
  Action Potentials Animals Imprinting (Psychology) Male Mental Recall Mice Mice, Inbred C57BL Neuronal Plasticity Neurons Optogenetics Photic Stimulation Synapses Visual Cortex

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• Source:
  Science. 353(6300):691-694.
• Pubmed ID:
  27516599
• Pubmed Central ID:
  PMC5482530
• Document Type:
  Journal Article
• Funding:
  R44MH109187/MH/NIMH NIH HHS/United States ; R01MH100561/MH/NIMH NIH HHS/United States ; R01MH101218/MH/NIMH NIH HHS/United States ; R01 MH101218/MH/NIMH NIH HHS/United States ; DP1 EY024503/EY/NEI NIH HHS/United States ; R01 EY011787/EY/NEI NIH HHS/United States ; R41MH100895/MH/NIMH NIH HHS/United States ; DP1EY024503/DP/NCCDPHP CDC HHS/United States ; R44 MH109187/MH/NIMH NIH HHS/United States ; R01EY011787/EY/NEI NIH HHS/United States
• Volume:
  353
• Issue:
  6300
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5d5b95c08f6a542c810261a580cd6ca8426f9427d91d8596c4ecc3abe6fe2c2c
• Download URL:
  https://stacks.cdc.gov/view/cdc/46385/cdc_46385_DS1.pdf
• File Type:
  [PDF - 1.84 MB ]