CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Inhibitory neuron transplantation into adult visual cortex creates a new critical period that rescues impaired vision
-
5 20 2015
-
-
Source: Neuron. 2015; 86(4):1055-1066
Details:
-
Alternative Title:Neuron
-
Personal Author:
-
Description:The maturation of inhibitory circuits in juvenile visual cortex triggers a critical period in the development of the visual system. Although several manipulations of inhibition can alter the timing of the critical period, none have demonstrated the creation of a new critical period in adulthood. We developed a transplantation method to reactivate critical period plasticity in the adult visual cortex. Transplanted embryonic inhibitory neurons from the medial ganglionic eminence reinstate ocular dominance plasticity in adult recipients. Transplanted inhibitory cells develop cell-type-appropriate molecular characteristics and visually evoked responses. In adult mice impaired by deprivation during the juvenile critical period, transplantation also recovers both visual cortical responses and performance on a behavioral test of visual acuity. Plasticity and recovery are induced when the critical period would have occurred in the donor animal. These results reveal that the focal reactivation of visual cortical plasticity using inhibitory cell transplantation creates a new critical period that restores visual perception after childhood deprivation.
-
Subjects:
-
Source:
-
Pubmed ID:25937171
-
Pubmed Central ID:PMC4441572
-
Document Type:
-
Funding:
-
Volume:86
-
Issue:4
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type: