Details:

Alternative Title:
Neuron
Publisher's site:
http://dx.doi.org/10.1016/j.neuron.2015.03.062
Personal Author:
Davis, Melissa F. ; Figueroa Velez, Dario X. ; Guevarra, Roblen P. ; Yang, Michael C. ; Habeeb, Mariyam ; ... More +
Davis, Melissa F. ; Figueroa Velez, Dario X. ; Guevarra, Roblen P. ; Yang, Michael C. ; Habeeb, Mariyam ; Carathedathu, Mathew C. ; Gandhi, Sunil P. ; Less -
Description:
The maturation of inhibitory circuits in juvenile visual cortex triggers a critical period in the development of the visual system. Although several manipulations of inhibition can alter the timing of the critical period, none have demonstrated the creation of a new critical period in adulthood. We developed a transplantation method to reactivate critical period plasticity in the adult visual cortex. Transplanted embryonic inhibitory neurons from the medial ganglionic eminence reinstate ocular dominance plasticity in adult recipients. Transplanted inhibitory cells develop cell-type-appropriate molecular characteristics and visually evoked responses. In adult mice impaired by deprivation during the juvenile critical period, transplantation also recovers both visual cortical responses and performance on a behavioral test of visual acuity. Plasticity and recovery are induced when the critical period would have occurred in the donor animal. These results reveal that the focal reactivation of visual cortical plasticity using inhibitory cell transplantation creates a new critical period that restores visual perception after childhood deprivation.
Subject:
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Aging
Animals
Article
Critical Period (Psychology)
Dominance, Ocular
Evoked Potentials, Visual
Mice, Inbred C57BL
Neural Inhibition
Neuronal Plasticity
Neurons
Sensory Deprivation
Vision, Ocular
Visual Cortex

Source:
Neuron. 2015; 86(4):1055-1066.
Pubmed ID:
25937171
Pubmed Central ID:
PMC4441572
Document Type:
Journal Article ;
Funding:
DP2 EY024504/EY/NEI NIH HHS/United States ; DP2 EY024504-01/DP/NCCDPHP CDC HHS/United States ;
DP2 EY024504/EY/NEI NIH HHS/United States ; DP2 EY024504-01/DP/NCCDPHP CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:d9f35777c6191bc06dd0b05c224ca0d5dca73b910f8ba97f08f23b1fb7f3a063
File Type:

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