Details:

Alternative Title:
Nat Commun
Personal Author:
Law, Philip J.; Berndt, Sonja I.; Speedy, Helen E.; Camp, Nicola J.; Sava, Georgina P.; ... More +
Law, Philip J.; Berndt, Sonja I.; Speedy, Helen E.; Camp, Nicola J.; Sava, Georgina P.; Skibola, Christine F.; Holroyd, Amy; Joseph, Vijai; Sunter, Nicola J.; Nieters, Alexandra; Bea, Silvia; Monnereau, Alain; Martin-Garcia, David; Goldin, Lynn R.; Clot, Guillem; Teras, Lauren R.; Quintela, Inés; Birmann, Brenda M.; Jayne, Sandrine; Cozen, Wendy; Majid, Aneela; Smedby, Karin E.; Lan, Qing; Dearden, Claire; Brooks-Wilson, Angela R.; Hall, Andrew G.; Purdue, Mark P.; Mainou-Fowler, Tryfonia; Vajdic, Claire M.; Jackson, Graham H.; Cocco, Pierluigi; Marr, Helen; Zhang, Yawei; Zheng, Tongzhang; Giles, Graham G.; Lawrence, Charles; Call, Timothy G.; Liebow, Mark; Melbye, Mads; Glimelius, Bengt; Mansouri, Larry; Glenn, Martha; Curtin, Karen; Diver, W Ryan; Link, Brian K.; Conde, Lucia; Bracci, Paige M.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Maynadie, Marc; McKay, James; Albanes, Demetrius; Weinstein, Stephanie; Wang, Zhaoming; Caporaso, Neil E.; Morton, Lindsay M.; Severson, Richard K.; Riboli, Elio; Vineis, Paolo; Vermeulen, Roel C. H.; Southey, Melissa C.; Milne, Roger L.; Clavel, Jacqueline; Topka, Sabine; Spinelli, John J.; Kraft, Peter; Ennas, Maria Grazia; Summerfield, Geoffrey; Ferri, Giovanni M.; Harris, Robert J.; Miligi, Lucia; Pettitt, Andrew R.; North, Kari E.; Allsup, David J.; Fraumeni, Joseph F.; Bailey, James R.; Offit, Kenneth; Pratt, Guy; Hjalgrim, Henrik; Pepper, Chris; Chanock, Stephen J.; Fegan, Chris; Rosenquist, Richard; de Sanjose, Silvia; Carracedo, Angel; Dyer, Martin J. S.; Catovsky, Daniel; Campo, Elias; Cerhan, James R.; Allan, James M.; Rothman, Nathanial; Houlston, Richard; Slager, Susan; Less -
Description:
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10(-13)), 1q42.13 (rs41271473, P=1.06 × 10(-10)), 4q24 (rs71597109, P=1.37 × 10(-10)), 4q35.1 (rs57214277, P=3.69 × 10(-8)), 6p21.31 (rs3800461, P=1.97 × 10(-8)), 11q23.2 (rs61904987, P=2.64 × 10(-11)), 18q21.1 (rs1036935, P=3.27 × 10(-8)), 19p13.3 (rs7254272, P=4.67 × 10(-8)) and 22q13.33 (rs140522, P=2.70 × 10(-9)). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.
Subject:
[+]
Adult
Antibody Formation
B-Lymphocytes
Case-Control Studies
Chromosome Mapping
Chromosomes, Human
Female
Genetic Predisposition To Disease
Genome-Wide Association Study
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Male
Middle Aged
Polymorphism, Single Nucleotide
Young Adult

Source:
Nat Commun. 2017; 8.;
Pubmed ID:
28165464
Pubmed Central ID:
PMC5303820
Document Type:
Journal Article;
Funding:
N01 PC067009/CN/NCI NIH HHS/United States; HHSN268201100001I/HL/NHLBI NIH HHS/United States; HHSN261201000035C/PC,CA/None/None; P30 CA016087/CA/NCI NIH HHS/United States; HHSN261201000140C/CA/NCI NIH HHS/United States; ... More +
N01 PC067009/CN/NCI NIH HHS/United States; HHSN268201100001I/HL/NHLBI NIH HHS/United States; HHSN261201000035C/PC,CA/None/None; P30 CA016087/CA/NCI NIH HHS/United States; HHSN261201000140C/CA/NCI NIH HHS/United States; N01 PC067010/PC/NCI NIH HHS/United States; R01 CA098122/CA/NCI NIH HHS/United States; U01 HG007033/HG/NHGRI NIH HHS/United States; P01 CA087969/CA/NCI NIH HHS/United States; HHSN261201000006C/CP/NCI NIH HHS/United States; R21 CA165923/CA/NCI NIH HHS/United States; HHSN268201100004I/HL/NHLBI NIH HHS/United States; UL1 TR001863/TR/NCATS NIH HHS/United States; R21 CA178800/CA/NCI NIH HHS/United States; HHSN268201100046C/HL/NHLBI NIH HHS/United States; P30 CA086862/CA/NCI NIH HHS/United States; N01 PC067008/PC/NCI NIH HHS/United States; HHSN268201100003C/WH/WHI NIH HHS/United States; R01 CA148690/CA/NCI NIH HHS/United States; P30 ES000260/ES/NIEHS NIH HHS/United States; U58 DP000807/DP/NCCDPHP CDC HHS/United States; R01 CA154643/CA/NCI NIH HHS/United States; R01 CA062006/CA/NCI NIH HHS/United States; N01 PC065064/PC/NCI NIH HHS/United States; K08 CA134919/CA/NCI NIH HHS/United States; UL1 TR000135/TR/NCATS NIH HHS/United States; HHSN271201100004C/AG/NIA NIH HHS/United States; R01 CA098661/CA/NCI NIH HHS/United States; UM1 CA186107/CA/NCI NIH HHS/United States; HHSN268201100002C/WH/WHI NIH HHS/United States; P30 CA015083/CA/NCI NIH HHS/United States; R01 CA092153/CA/NCI NIH HHS/United States; HHSN261201000035I/CA/NCI NIH HHS/United States; HHSN261201000034C/CA/NCI NIH HHS/United States; UM1 CA167552/CA/NCI NIH HHS/United States; N01RC37004/RC/CCR NIH HHS/United States; R01 CA087014/CA/NCI NIH HHS/United States; P50 CA097274/CA/NCI NIH HHS/United States; R01 CA049449/CA/NCI NIH HHS/United States; HHSN268201100002I/HL/NHLBI NIH HHS/United States; KL2 TR001862/TR/NCATS NIH HHS/United States; N01CO12400/CA/NCI NIH HHS/United States; N01 CN045165/CN/NCI NIH HHS/United States; U01 CA049449/CA/NCI NIH HHS/United States; R01 CA149445/CA/NCI NIH HHS/United States; R01 CA134674/CA/NCI NIH HHS/United States; R01 CA045614/CA/NCI NIH HHS/United States; HHSN261201000026C/CA/NCI NIH HHS/United States; HHSN268201100001C/WH/WHI NIH HHS/United States; HHSN268201100004C/WH/WHI NIH HHS/United States; U01 CA118444/CA/NCI NIH HHS/United States; P30 CA042014/CA/NCI NIH HHS/United States; R03 CA089745/CA/NCI NIH HHS/United States; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:fe5fd98c1025e11cc26e600339fea6fa6f371a72ffc5633e8865dbbfa627cf4a
File Type:

Supporting Files

• 	ncomms14175-f5.gif	gif
  	ncomms14175-f5.jpg	jpeg
  	ncomms14175-s1.pdf	pdf
  	ncomms14175-s2.xlsx	xlsx
  	ncomms14175-s3.xlsx	xlsx
  	ncomms14175-s4.xlsx	xlsx
  	ncomms14175-s5.pdf	pdf
  	ncomms14175.nxml	xml
  	ncomms14175-f1.gif	gif
  	ncomms14175-f1.jpg	jpeg
  	ncomms14175-f2.gif	gif
  	ncomms14175-f2.jpg	jpeg
  	ncomms14175-f3.gif	gif
  	ncomms14175-f3.jpg	jpeg
  	ncomms14175-f4.gif	gif
  	ncomms14175-f4.jpg	jpeg

More +