Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Law, Philip J.; Berndt, Sonja I.; Speedy, Helen E.; Camp, Nicola J.; Sava, Georgina P.; Skibola, Christine F.; Holroyd, Amy; Joseph, Vijai; Sunter, Nicola J.; Nieters, Alexandra; Bea, Silvia; Monnereau, Alain; Martin-Garcia, David; Goldin, Lynn R.; Clot, Guillem; Teras, Lauren R.; Quintela, Inés; Birmann, Brenda M.; Jayne, Sandrine; Cozen, Wendy; Majid, Aneela; Smedby, Karin E.; Lan, Qing; Dearden, Claire; Brooks-Wilson, Angela R.; Hall, Andrew G.; Purdue, Mark P.; Mainou-Fowler, Tryfonia; Vajdic, Claire M.; Jackson, Graham H.; Cocco, Pierluigi; Marr, Helen; Zhang, Yawei; Zheng, Tongzhang; Giles, Graham G.; Lawrence, Charles; Call, Timothy G.; Liebow, Mark; Melbye, Mads; Glimelius, Bengt; Mansouri, Larry; Glenn, Martha; Curtin, Karen; Diver, W Ryan; Link, Brian K.; Conde, Lucia; Bracci, Paige M.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Maynadie, Marc; McKay, James; Albanes, Demetrius; Weinstein, Stephanie; Wang, Zhaoming; Caporaso, Neil E.; Morton, Lindsay M.; Severson, Richard K.; Riboli, Elio; Vineis, Paolo; Vermeulen, Roel C. H.; Southey, Melissa C.; Milne, Roger L.; Clavel, Jacqueline; Topka, Sabine; Spinelli, John J.; Kraft, Peter; Ennas, Maria Grazia; Summerfield, Geoffrey; Ferri, Giovanni M.; Harris, Robert J.; Miligi, Lucia; Pettitt, Andrew R.; North, Kari E.; Allsup, David J.; Fraumeni, Joseph F.; Bailey, James R.; Offit, Kenneth; Pratt, Guy; Hjalgrim, Henrik; Pepper, Chris; Chanock, Stephen J.; Fegan, Chris; Rosenquist, Richard; de Sanjose, Silvia; Carracedo, Angel; Dyer, Martin J. S.; Catovsky, Daniel; Campo, Elias; Cerhan, James R.; Allan, James M.; Rothman, Nathanial; Houlston, Richard; Slager, Susan

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Published Date:

Feb 06 2017

Source:

Nat Commun. 2017; 8.

[PDF - 953.20 KB]

Details:

Personal Authors:

Law, Philip J. ; Berndt, Sonja I. ; Speedy, Helen E. ; Camp, Nicola J. ; Sava, Georgina P. ; ... More ▼

Pubmed ID:

28165464

Pubmed Central ID:

PMC5303820

Description:

Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10(-13)), 1q42.13 (rs41271473, P=1.06 × 10(-10)), 4q24 (rs71597109, P=1.37 × 10(-10)), 4q35.1 (rs57214277, P=3.69 × 10(-8)), 6p21.31 (rs3800461, P=1.97 × 10(-8)), 11q23.2 (rs61904987, P=2.64 × 10(-11)), 18q21.1 (rs1036935, P=3.27 × 10(-8)), 19p13.3 (rs7254272, P=4.67 × 10(-8)) and 22q13.33 (rs140522, P=2.70 × 10(-9)). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

N01 PC067009/CN/NCI NIH HHS/United States
HHSN268201100001I/HL/NHLBI NIH HHS/United States
HHSN261201000035C/PC,CA/None/None
P30 CA016087/CA/NCI NIH HHS/United States
HHSN261201000140C/CA/NCI NIH HHS/United States
N01 PC067010/PC/NCI NIH HHS/United States
R01 CA098122/CA/NCI NIH HHS/United States
U01 HG007033/HG/NHGRI NIH HHS/United States
P01 CA087969/CA/NCI NIH HHS/United States
HHSN261201000006C/CP/NCI NIH HHS/United States
R21 CA165923/CA/NCI NIH HHS/United States
HHSN268201100004I/HL/NHLBI NIH HHS/United States
UL1 TR001863/TR/NCATS NIH HHS/United States
R21 CA178800/CA/NCI NIH HHS/United States
HHSN268201100046C/HL/NHLBI NIH HHS/United States
P30 CA086862/CA/NCI NIH HHS/United States
N01 PC067008/PC/NCI NIH HHS/United States
HHSN268201100003C/WH/WHI NIH HHS/United States
R01 CA148690/CA/NCI NIH HHS/United States
P30 ES000260/ES/NIEHS NIH HHS/United States
U58 DP000807/DP/NCCDPHP CDC HHS/United States
R01 CA154643/CA/NCI NIH HHS/United States
R01 CA062006/CA/NCI NIH HHS/United States
N01 PC065064/PC/NCI NIH HHS/United States
K08 CA134919/CA/NCI NIH HHS/United States
UL1 TR000135/TR/NCATS NIH HHS/United States
HHSN271201100004C/AG/NIA NIH HHS/United States
R01 CA098661/CA/NCI NIH HHS/United States
UM1 CA186107/CA/NCI NIH HHS/United States
HHSN268201100002C/WH/WHI NIH HHS/United States
P30 CA015083/CA/NCI NIH HHS/United States
R01 CA092153/CA/NCI NIH HHS/United States
HHSN261201000035I/CA/NCI NIH HHS/United States
HHSN261201000034C/CA/NCI NIH HHS/United States
UM1 CA167552/CA/NCI NIH HHS/United States
N01RC37004/RC/CCR NIH HHS/United States
R01 CA087014/CA/NCI NIH HHS/United States
P50 CA097274/CA/NCI NIH HHS/United States
R01 CA049449/CA/NCI NIH HHS/United States
HHSN268201100002I/HL/NHLBI NIH HHS/United States
KL2 TR001862/TR/NCATS NIH HHS/United States
N01CO12400/CA/NCI NIH HHS/United States
N01 CN045165/CN/NCI NIH HHS/United States
U01 CA049449/CA/NCI NIH HHS/United States
R01 CA149445/CA/NCI NIH HHS/United States
R01 CA134674/CA/NCI NIH HHS/United States
R01 CA045614/CA/NCI NIH HHS/United States
HHSN261201000026C/CA/NCI NIH HHS/United States
HHSN268201100001C/WH/WHI NIH HHS/United States
HHSN268201100004C/WH/WHI NIH HHS/United States
U01 CA118444/CA/NCI NIH HHS/United States
P30 CA042014/CA/NCI NIH HHS/United States
R03 CA089745/CA/NCI NIH HHS/United States

Supporting Files:

ncomms14175-f1.gif	image/gif
ncomms14175-f1.jpg	image/jpeg
ncomms14175-f2.gif	image/gif
ncomms14175-f2.jpg	image/jpeg
ncomms14175-f3.gif	image/gif
ncomms14175-f3.jpg	image/jpeg
ncomms14175-f4.gif	image/gif
ncomms14175-f4.jpg	image/jpeg
ncomms14175-f5.gif	image/gif
ncomms14175-f5.jpg	image/jpeg
ncomms14175-s1.pdf	application/pdf
ncomms14175-s2.xlsx	application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
ncomms14175-s3.xlsx	application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
ncomms14175-s4.xlsx	application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
ncomms14175-s5.pdf	application/pdf
ncomms14175.nxml	application/octet-stream

No Related Documents.

You May Also Like:

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Personal Author:

Berndt, Sonja I.; Camp, Nicola J.; Skibola, Christine F.; Vijai, Joseph; Wang, Zhaoming; Gu, Jian; Nieters, Alexandra; Kelly, Rachel S.; Smedby, Karin E.; Monnereau, Alain; Cozen, Wendy; Cox, Angela; Wang, Sophia S.; Lan, Qing; Teras, Lauren R.; Machado, Moara; Yeager, Meredith; Brooks-Wilson, Angela R.; Hartge, Patricia; Purdue, Mark P.; Birmann, Brenda M.; Vajdic, Claire M.; Cocco, Pierluigi; Zhang, Yawei; Giles, Graham G.; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Montalvan, Rebecca; Burdett, Laurie; Hutchinson, Amy; Ye, Yuanqing; Call, Timothy G.; Shanafelt, Tait D.; Novak, Anne J.; Kay, Neil E.; Liebow, Mark; Cunningham, Julie M.; Allmer, Cristine; Hjalgrim, Henrik; Adami, Hans-Olov; Melbye, Mads; Glimelius, Bengt; Chang, Ellen T.; Glenn, Martha; Curtin, Karen; Cannon-Albright, Lisa A.; Diver, W Ryan; Link, Brian K.; Weiner, George J.; Conde, Lucia; Bracci, Paige M.; Riby, Jacques; Arnett, Donna K.; Zhi, Degui; Leach, Justin M.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Benavente, Yolanda; Sala, Núria; Casabonne, Delphine; Becker, Nikolaus; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; Chaffee, Kari G.; Achenbach, Sara J.; Vachon, Celine M.; Goldin, Lynn R.; Strom, Sara S.; Leis, Jose F.; Weinberg, J. Brice; Caporaso, Neil E.; Norman, Aaron D.; De Roos, Anneclaire J.; Morton, Lindsay M.; Severson, Richard K.; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Masala, Giovanna; Weiderpass, Elisabete; Chirlaque, María- Dolores; Vermeulen, Roel C. H.; Travis, Ruth C.; Southey, Melissa C.; Milne, Roger L.; Albanes, Demetrius; Virtamo, Jarmo; Weinstein, Stephanie; Clavel, Jacqueline; Zheng, Tongzhang; Holford, Theodore R.; Villano, Danylo J.; Maria, Ann; Spinelli, John J.; Gascoyne, Randy D.; Connors, Joseph M.; Bertrand, Kimberly A.; Giovannucci, Edward; Kraft, Peter; Kricker, Anne; Turner, Jenny; Ennas, Maria Grazia; Ferri, Giovanni M.; Miligi, Lucia; Liang, Liming; Ma, Baoshan; Huang, Jinyan; Crouch, Simon; Park, Ju-Hyun; Chatterjee, Nilanjan; North, Kari E.; Snowden, John A.; Wright, Josh; Fraumeni, Joseph F.; Offit, Kenneth; Wu, Xifeng; de Sanjose, Silvia; Cerhan, James R.; Chanock, Stephen J.; Rothman, Nathaniel; Slager, Susan L.;

Published:

Mar 09 2016

Source:

Nat Commun. 2016; 7.

Description:

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide asso...

File Type:

[PDF - 1.02 MB]
Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes

Personal Author:

Zhang, Qibin; Fillmore, Thomas L.; Schepmoes, Athena A.; Clauss, Therese R.W.; Gritsenko, Marina A.; Mueller, Patricia W.; Rewers, Marian; Atkinson, Mark A.; Smith, Richard D.; Metz, Thomas O.;

Published:

Dec 31 2012

Source:

J Exp Med. 2013; 210(1):191-203.

Description:

Using global liquid chromatography-mass spectrometry (LC-MS)-based proteomics analyses, we identified 24 serum proteins that were significantly variant between those with type 1 diabetes (T1D) and healthy controls. Functionally, these proteins repres...

File Type:

[PDF - 1.84 MB]
A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia

Personal Author:

Milton, Jacqueline N.; Sebastiani, Paola; Solovieff, Nadia; Hartley, Stephen W.; Bhatnagar, Pallav; Arking, Dan E.; Dworkis, Daniel A.; Casella, James F.; Barron-Casella, Emily; Bean, Christopher J.; Hooper, W. Craig; DeBaun, Michael R.; Garrett, Melanie E.; Soldano, Karen; Telen, Marilyn J.; Ashley-Koch, Allison; Gladwin, Mark T.; Baldwin, Clinton T.; Steinberg, Martin H.; Klings, Elizabeth S.;

Published:

Apr 27 2012

Source:

PLoS One. 2012; 7(4).

Description:

Serum bilirubin levels have been associated with polymorphisms in the UGT1A1 promoter in normal populations and in patients with hemolytic anemias, including sickle cell anemia. When hemolysis occurs circulating heme increases, leading to elevated bi...

File Type:

[PDF - 355.81 KB]
A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q

Personal Author:

Heit, John A.; Armasu, Sebastian M.; Asmann, Yan W.; Cunningham, Julie M.; Matsumoto, Martha E.; Petterson, Tanya M.; de Andrade, Mariza;

Published:

Aug 2012

Source:

J Thromb Haemost. 2012; 10(8):1521-1531.

Description:

Objectives : To identify venous thromboembolism (VTE) disease-susceptibility genes. : Patients/Methods : We performed in silico genome wide association (GWAS) analyses using genotype data imputed to ~2.5 million single nucleotide polymorphisms (SNPs)...

File Type:

[PDF - 1.03 MB]
GENOME WIDE IDENTIFICATION OF NEW GENES AND PATHWAYS IN PATIENTS WITH BOTH AUTOIMMUNE THYROIDITIS AND TYPE 1 DIABETES

Personal Author:

Tomer, Yaron; Dolan, Lawrence M.; Kahaly, George; Divers, Jasmin; D’Agostino, Ralph B.; Imperatore, Giuseppina; Dabelea, Dana; Marcovina, Santica; Black, Mary Helen; Pihoker, Catherine; Hasham, Alia; Salehi Hammerstad, Sara; Greenberg, David A.; Lotay, Vaneet; Zhang, Weijia; Monti, Maria Cristina; Matheis, Nina;

Published:

Apr 27 2015

Source:

J Autoimmun. 2015; 60:32-39.

Description:

Autoimmune thyroid diseases (AITD) and Type 1 diabetes (T1D) frequently occur in the same individual pointing to a strong shared genetic susceptibility. Indeed, the co-occurrence of T1D and AITD in the same individual is classified as a variant of th...

File Type:

[PDF - 1.28 MB]