Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Otieno, James R. ; Kamau, Everlyn M. ; Agoti, Charles N. ; Lewa, Clement ; Otieno, Grieven ; ... More +
Otieno, James R. ; Kamau, Everlyn M. ; Agoti, Charles N. ; Lewa, Clement ; Otieno, Grieven ; Bett, Ann ; Ngama, Mwanajuma ; Cane, Patricia A. ; Nokes, D. James ; Less -
Description:
In February 2012, the novel respiratory syncytial virus (RSV) group A, genotype ON1, was detected in Kilifi County, coastal Kenya. ON1 is characterized by a 72-nt duplication within the highly variable G gene (encoding the immunogenic attachment surface protein). Cases were diagnosed through surveillance of pneumonia in children at the county hospital. Analysis of epidemiologic, clinical, and sequence data of RSV-A viruses detected over 5 RSV seasons (2010/2011 to 2014/2015) indicated the following: 1) replacement of previously circulating genotype GA2 ON1, 2) an abrupt expansion in the number of ON1 variants detected in the 2014/2015 epidemic, 3) recently accumulation of amino acid substitutions within the ON1 duplicated sequence, and 4) no clear evidence of altered pathogenicity relative to GA2. The study demonstrates the public health importance of molecular surveillance in defining the spread, clinical effects, and evolution of novel respiratory virus variants.
Subject:
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Evolutionary Dynamics
Genetic Diversity
G Protein
Phylogenetic Analysis
Research
Respiratory Diseases
Respiratory Infections
Respiratory Syncytial Virus
RSV
Spread And Evolution Of Respiratory Syncytial Virus A Genotype ON1, Coastal Kenya, 2010–2015
Viruses

Source:
Emerg Infect Dis. 23(2):264-271. ;
Pubmed ID:
28098528
Pubmed Central ID:
PMC5324789
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:ab475848eec5ac61b5990e19b85d208ad7d50b3d97c50e3f445f79481bcb8c13
File Type:

Supporting Files

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