Respiratory syncytial virus in adults with severe acute respiratory illness in a high HIV prevalence setting

Moyes, Jocelyn; Walaza, Sibongile; Pretorius, Marthi; Groome, Michelle; von Gottberg, Anne; Wolter, Nicole; Haffejee, Sumayya; Variava, Ebrahim; Cohen, Adam L.; Tempia, Stefano; Kahn, Kathleen; Dawood, Halima; Venter, Marietjie; Cohen, Cheryl; Madhi, Shabir A.

doi:10.1016/j.jinf.2017.06.007

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

i

Respiratory syncytial virus in adults with severe acute respiratory illness in a high HIV prevalence setting

10 2017
By Moyes, Jocelyn ; Walaza, Sibongile ; Pretorius, Marthi ; ...
http://dx.doi.org/10.1016/j.jinf.2017.06.007
Source: J Infect. 75(4):346-355

[PDF-276.35 KB]

English

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Details:

Alternative Title:

J Infect
Personal Author:

Moyes, Jocelyn ; Walaza, Sibongile ; Pretorius, Marthi ; Groome, Michelle ; von Gottberg, Anne ; ... More +

Moyes, Jocelyn ; Walaza, Sibongile ; Pretorius, Marthi ; Groome, Michelle ; von Gottberg, Anne ; Wolter, Nicole ; Haffejee, Sumayya ; Variava, Ebrahim ; Cohen, Adam L. ; Tempia, Stefano ; Kahn, Kathleen ; Dawood, Halima ; Venter, Marietjie ; Cohen, Cheryl ; Madhi, Shabir A. Less -
Corporate Authors:

for the South African Severe Acute Respiratory Illness (SARI) Surveillance Group
Description:

Background

There are limited data on the epidemiology of respiratory syncytial virus (RSV) illness in HIV-infected adults or the elderly in Africa. We studied the epidemiology of RSV-associated severe acute respiratory illness (SARI) hospitalizations in adults in South Africa from 2009 through 2013.

Methods

Individuals admitted to sentinel surveillance hospitals were investigated by respiratory tract swabs for RSV, using a multiplex real-time polymerase chain reaction assay. The incidence of RSV-associated SARI was calculated for the one site with population denominators.

Results

Of 7796 participants investigated, 329 (4%) tested positive for RSV. On multivariable analysis, HIV-infected individuals with RSV-associated SARI had greater odds of being in the age groups 18–44 and 45–64 years (odd ratios (OR) 26.3; 95% confidence interval (CI) 6.2–112.1 and OR 11.4; 95% CI 2.6–50.0) compared with those ≥65 years and being female (OR 2.7; 95% CI 1.4–5.4). The relative risk of hospitalization with RSV-associated SARI was 12–18 times higher in HIV infected individual compared to that of HIV-uninfected.

Conclusion

The incidence of RSV-associated SARI was higher in HIV-infected individuals and those aged 65 years and older. Further studies are warranted to describe the disease association of RSV detected in adults with SARI.
Keywords:

[+]

Acute Disease Adolescent Adult Aged Child, Preschool Female HIV HIV Infections Hospitalization Humans Infant Male Middle Aged Population Surveillance Prevalence Real-Time Polymerase Chain Reaction Respiratory Syncytial Respiratory Syncytial Virus, Human Respiratory Syncytial Virus Infections Respiratory Tract Infections Sentinel Surveillance South Africa Virus Young Adult
Source:

J Infect. 75(4):346-355
Pubmed ID:

28676408
Pubmed Central ID:

PMC5712433
Document Type:

Journal Article
Funding:

001/WHO_/World Health OrganizationInternational/ ; U01 IP001048/IP/NCIRD CDC HHSUnited States/ ; U51 IP000155/IP/NCIRD CDC HHSUnited States/ ; U51 IP000528/IP/NCIRD CDC HHSUnited States/

001/WHO_/World Health OrganizationInternational/ ; U01 IP001048/IP/NCIRD CDC HHSUnited States/ ; U51 IP000155/IP/NCIRD CDC HHSUnited States/ ; U51 IP000528/IP/NCIRD CDC HHSUnited States/ Less -
Volume:

75
Issue:

4
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:0dad95cdc25623cf79469e9d632cfefdc7bbe1ae0ddb2280fa1d0eeeb9154e1e
Download URL:

https://stacks.cdc.gov/view/cdc/50448/cdc_50448_DS1.pdf
File Type:

	nihms921069.nxml	xml
	nihms921069f1.gif	gif
	nihms921069f1.jpg	jpeg

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