Respiratory syncytial virus in adults with severe acute respiratory illness in a high HIV prevalence setting

Details

• Alternative Title:
  J Infect
• Personal Author:
  Moyes, Jocelyn ; Walaza, Sibongile ; Pretorius, Marthi ; Groome, Michelle ; von Gottberg, Anne ; Wolter, Nicole ; Haffejee, Sumayya ; Variava, Ebrahim ; Cohen, Adam L. ; Tempia, Stefano ; Kahn, Kathleen ; Dawood, Halima ; Venter, Marietjie ; Cohen, Cheryl ; Madhi, Shabir A.
  More +
• Corporate Authors:
  for the South African Severe Acute Respiratory Illness (SARI) Surveillance Group
• Description:
  Background ; There are limited data on the epidemiology of respiratory syncytial virus (RSV) illness in HIV-infected adults or the elderly in Africa. We studied the epidemiology of RSV-associated severe acute respiratory illness (SARI) hospitalizations in adults in South Africa from 2009 through 2013. ; Methods ; Individuals admitted to sentinel surveillance hospitals were investigated by respiratory tract swabs for RSV, using a multiplex real-time polymerase chain reaction assay. The incidence of RSV-associated SARI was calculated for the one site with population denominators. ; Results ; Of 7796 participants investigated, 329 (4%) tested positive for RSV. On multivariable analysis, HIV-infected individuals with RSV-associated SARI had greater odds of being in the age groups 18–44 and 45–64 years (odd ratios (OR) 26.3; 95% confidence interval (CI) 6.2–112.1 and OR 11.4; 95% CI 2.6–50.0) compared with those ≥65 years and being female (OR 2.7; 95% CI 1.4–5.4). The relative risk of hospitalization with RSV-associated SARI was 12–18 times higher in HIV infected individual compared to that of HIV-uninfected. ; Conclusion ; The incidence of RSV-associated SARI was higher in HIV-infected individuals and those aged 65 years and older. Further studies are warranted to describe the disease association of RSV detected in adults with SARI.
• Keywords:
  • Respiratory syncytial
  • virus
  • HIV
  • South Africa
  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Child, Preschool
  • Female
  More +
• Source:
  J Infect. 75(4):346-355
• Pubmed ID:
  28676408
• Pubmed Central ID:
  PMC5712433
• Document Type:
  Journal Article
• Funding:
  001/WHO_/World Health OrganizationInternational/ ; U01 IP001048/IP/NCIRD CDC HHSUnited States/ ; U51 IP000155/IP/NCIRD CDC HHSUnited States/ ; U51 IP000528/IP/NCIRD CDC HHSUnited States/
• Volume:
  75
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/50448/cdc_50448_DS1.pdf
• File Type:
  [PDF - 276.35 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0dad95cdc25623cf79469e9d632cfefdc7bbe1ae0ddb2280fa1d0eeeb9154e1e