Known Unknowns of Cardiolipin Signaling: The Best Is Yet To Come

Details

• Alternative Title:
  Biochim Biophys Acta
• Personal Author:
  Maguire, John J. ; Tyurina, Yulia Y. ; Mohammadyani, Dariush ; Kapralov, Aleksandr A. ; Anthonymuthu, Tamil S. ; Qu, Feng ; Amoscato, Andrew A. ; Sparvero, Louis J. ; Tyurin, Vladimir A. ; Planas-Iglesias, Joan ; He, Rong-Rong ; Klein-Seetharaman, Judith ; Bayır, Hülya ; Kagan, Valerian E.
• Description:
  Since its discovery 75years ago, a wealth of knowledge has accumulated on the role of cardiolipin, the hallmark phospholipid of mitochondria, in bioenergetics and particularly on the structural organization of the inner mitochondrial membrane. A surge of interest in this anionic doubly-charged tetra-acylated lipid found in both prokaryotes and mitochondria has emerged based on its newly discovered signaling functions. Cardiolipin displays organ, tissue, cellular and transmembrane distribution asymmetries. A collapse of the membrane asymmetry represents a pro-mitophageal mechanism whereby externalized cardiolipin acts as an "eat-me" signal. Oxidation of cardiolipin's polyunsaturated acyl chains - catalyzed by cardiolipin complexes with cytochrome c. - is a pro-apoptotic signal. The messaging functions of myriads of cardiolipin species and their oxidation products are now being recognized as important intracellular and extracellular signals for innate and adaptive immune systems. This newly developing field of research exploring cardiolipin signaling is the main subject of this review. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
• Subjects:
  Animals Cardiolipins Cytochromes C Humans Mitochondria Mitochondrial Membranes Oxidation-Reduction Phospholipids Signal Transduction
• Keywords:
  Apoptosis Cardiolipin Oxidation Cardiolipin Signaling Innate And Adaptive Immunity Mitophagy Peroxidase
• Source:
  Biochim Biophys Acta. 1862(1):8-24
• Pubmed ID:
  27498292
• Pubmed Central ID:
  PMC5323096
• Document Type:
  Journal Article
• Funding:
  R01 CA165065/CA/NCI NIH HHSUnited States/ ; R01 ES020693/ES/NIEHS NIH HHSUnited States/ ; R01 OH008282/OH/NIOSH CDC HHSUnited States/ ; U19 AI068021/AI/NIAID NIH HHSUnited States/ ; R37 NS061817/NS/NINDS NIH HHSUnited States/ ; R01 NS076511/NS/NINDS NIH HHSUnited States/ ; R01 NS061817/NS/NINDS NIH HHSUnited States/ ; P01 HL114453/HL/NHLBI NIH HHSUnited States/
• Volume:
  1862
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:39b6f03f596c62eb55eb150713c59679085aff0eb08a10ad893007dd068d7df6ed74d17464bcb73927109819e08f37ac1bfd561a25138a6f76acf6706a47ec67
• Download URL:
  https://stacks.cdc.gov/view/cdc/44350/cdc_44350_DS1.pdf
• File Type:
  [PDF - 3.33 MB ]