Known Unknowns of Cardiolipin Signaling: The Best Is Yet to Come

Details

• Personal Author:
  Amoscato AA ; Anthonymuthu TS ; Bayir H ; He R-R ; Kagan VE ; Kapralov AA ; Klein-Seetharaman J ; Maguire JJ ; Mohammadyani D ; Planas-Iglesias J ; Qua F ; Sparvero LJ ; Tyurin VA ; Tyurina YY
• Description:
  Since its discovery 75 years ago, a wealth of knowledge has accumulated on the role of cardiolipin, the hallmark phospholipid of mitochondria, in bioenergetics and particularly on the structural organization of the inner mitochondrial membrane. A surge of interest in this anionic doubly-charged tetra-acylated lipid found in both prokaryotes and mitochondria has emerged based on its newly discovered signaling functions. Cardiolipin displays organ, tissue, cellular and transmembrane distribution asymmetries. A collapse of the membrane asymmetry represents a pro-mitophageal mechanism whereby externalized cardiolipin acts as an "eat-me" signal. Oxidation of cardiolipin's polyunsaturated acyl chains - catalyzed by cardiolipin complexes with cytochrome c. - is a proapoptotic signal. The messaging functions of myriads of cardiolipin species and their oxidation products are now being recognized as important intracellular and extracellular signals for innate and adaptive immune systems. This newly developing field of research exploring cardiolipin signaling is themain subject of this review. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Enzymes Immune System Lipids Occupational Health Safety
• Keywords:
  Apoptosis Author Keywords: Cardiolipin Signaling Bioenergetics Biological Systems Cardiolipin Oxidation Cell Biology Cell Damage Cell Death Cell Function Cell Metabolism Cell Signaling Immune Reaction Innate And Adaptive Immunity Mitophagy Oxidation Peroxidase Peroxidases Phospholipids

  More +
• ISSN:
  1388-1981
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8-24
• Volume:
  1862
• Issue:
  1
• NIOSHTIC Number:
  nn:20049945
• Citation:
  Biochim Biophys Acta, Mole Cell Biol Lipids 2017 Jan; 1862(1):8-24
• Contact Point Address:
  Valerian E. Kagan, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
• Email:
  kagan@pitt.edu
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:98eba3110826abde9d793b82b1443c6751f093d66add558c605556d94eadf121d22e20336ada213331d932567077bb812e11b53fcf90baa50e5ca544323e1b69
• Download URL:
  https://stacks.cdc.gov/view/cdc/210531/cdc_210531_DS1.pdf
• File Type:
  [PDF - 2.74 MB ]