Vertebrate Host Susceptibility to Heartland Virus

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bosco-Lauth, Angela M. ; Calvert, Amanda E. ; Root, J. Jeffrey ; Gidlewski, Tom ; Bird, Brian H. ; Bowen, Richard A. ; Muehlenbachs, Atis ; Zaki, Sherif R. ; Brault, Aaron C.
• Description:
  Heartland virus (HRTV) is a recently described phlebovirus initially isolated in 2009 from 2 humans who had leukopenia and thrombocytopenia. Serologic assessment of domestic and wild animal populations near the residence of 1 of these persons showed high exposure rates to raccoons, white-tailed deer, and horses. To our knowledge, no laboratory-based assessments of viremic potential of animals infected with HRTV have been performed. We experimentally inoculated several vertebrates (raccoons, goats, chickens, rabbits, hamsters, C57BL/6 mice, and interferon-α/β/γ receptor-deficient Ag129) mice with this virus. All animals showed immune responses against HRTV after primary or secondary exposure. However, neutralizing antibody responses were limited. Only Ag129 mice showed detectable viremia and associated illness and death, which were dose dependent. Ag129 mice also showed development of mean peak viral antibody titers >8 log10 PFU/mL, hemorrhagic hepatic lesions, splenomegaly, and large amounts of HRTV antigen in mononuclear cells and hematopoietic cells in the spleen.
• Subjects:
  • Research
  • Animal Diseases
  • Animals
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Biopsy
  • Bunyaviridae Infections
  • Cricetinae
  • Disease Models, Animal
  • Disease Susceptibility
  More +
• Source:
  Emerg Infect Dis. 22(12):2070-2077.
• Pubmed ID:
  27869591
• Pubmed Central ID:
  PMC5189141
• Document Type:
  Journal Article
• Volume:
  22
• Issue:
  12
• Download URL:
  https://stacks.cdc.gov/view/cdc/43434/cdc_43434_DS1.pdf
• File Type:
  [PDF - 1.50 MB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:573dc9ec708d15f932033edb20bf86ce264ca3c7037b325caddf6731f21ae48e