Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples

Chowdhury, Goutam; Pazhani, Gururaja Perumal; Sarkar, Anirban; Rajendran, Krishnan; Mukhopadhyay, Asish K.; Bhattacharya, Mihir K.; Ghosh, Amit; Ramamurthy, Thandavarayan

doi:10.3201/eid2210.151612

i

Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples

Supporting Files Public Domain

Oct 2016
By Chowdhury, Goutam ; Pazhani, Gururaja Perumal ; Sarkar, Anirban ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Chowdhury, Goutam ; Pazhani, Gururaja Perumal ; Sarkar, Anirban ; Rajendran, Krishnan ; Mukhopadhyay, Asish K. ; Bhattacharya, Mihir K. ; Ghosh, Amit ; Ramamurthy, Thandavarayan
Description:

Carbapenems have been used for many years to treat severe nosocomial Enterobacteriaceae infections. The spread of resistance to these drugs among other bacterial families is an emerging problem worldwide, mostly caused by New Delhi metallo-β-lactamase (NDM-1). We screened for the prevalence of NDM-1-expressing enteric pathogens from hospitalized patients with acute diarrhea in Kolkata, India, and identified 27 Vibrio fluvialis-harboring blaNDM-1 (NDM-VF) strains. These isolates were also resistant to all the tested antimicrobial drugs except doxycycline. The large plasmid of V. fluvialis harboring blaNDM-1 could be easily transferred to other enteric pathogens. Genes flanking the blaNDM-1 were found to be identical to the reported sequence from an Escherichia coli isolate. Analyses showed that the V. fluvialis possessing the NDM-VF region belonged to different clones. The pathogenicity of V. fluvialis to humans and its ubiquitous presence in the environment call for constant monitoring of this species for emerging antimicrobial drug resistance.
Subjects:

Anti-Bacterial Agents Beta-Lactamases Beta-Lactam Resistance Carbapenems Conjugation, Genetic Diarrhea Drug Resistance, Multiple, Bacterial Enterobacteriaceae Enterobacteriaceae Infections Escherichia Coli Gene Transfer, Horizontal Humans Microbial Sensitivity Tests R Factors Species Specificity Vibrio
Source:

Emerg Infect Dis. 22(10):1754-1761.
Pubmed ID:

27649032
Pubmed Central ID:

PMC5038395
Document Type:

Journal Article
Place as Subject:

India
Volume:

22
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:113c674c781f8fc5cc223b180f3418858990099f06a1700ae529a4b66ce15f3e
Download URL:

https://stacks.cdc.gov/view/cdc/42744/cdc_42744_DS1.pdf
File Type:

[PDF - 1.12 MB ]

File Language:

English

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