Carbapenem-Resistant enterobacterales in individuals with and without health care risk factors —Emerging infections program, United States, 2012-2015

Bulens, Sandra N.; Reses, Hannah E.; Ansari, Uzma A.; Grass, Julian E.; Carmon, Clayton; Albrecht, Valerie; Lawsin, Adrian; McAllister, Gillian; Daniels, Jonathan; Lee, Yeon-Kyeng; Yi, Sarah; See, Isaac; Jacob, Jesse T.; Bower, Chris W.; Wilson, Lucy; Vaeth, Elisabeth; Lynfield, Ruth; Vagnone, Paula Snippes; Shaw, Kristin M.; Dumyati, Ghinwa; Tsay, Rebecca; Phipps, Erin C.; Bamberg, Wendy; Janelle, Sarah J.; Beldavs, Zintars G.; Cassidy, P. Maureen; Kainer, Marion; Muleta, Daniel; Mounsey, Jacquelyn T.; Laufer-Halpin, Alison; Karlsson, Maria; Lutgring, Joseph D.; Walters, Maroya Spalding

doi:10.1016/j.ajic.2022.04.003

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Carbapenem-Resistant enterobacterales in individuals with and without health care risk factors —Emerging infections program, United States, 2012-2015

1 2023
By Bulens, Sandra N. ; Reses, Hannah E. ; Ansari, Uzma A. ; ...
http://dx.doi.org/10.1016/j.ajic.2022.04.003
Source: Am J Infect Control. 51(1):70-77

[PDF-383.14 KB]

English

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Details:

Alternative Title:

Am J Infect Control
Personal Author:

Bulens, Sandra N. ; Reses, Hannah E. ; Ansari, Uzma A. ; Grass, Julian E. ; Carmon, Clayton ; ... More +

Bulens, Sandra N. ; Reses, Hannah E. ; Ansari, Uzma A. ; Grass, Julian E. ; Carmon, Clayton ; Albrecht, Valerie ; Lawsin, Adrian ; McAllister, Gillian ; Daniels, Jonathan ; Lee, Yeon-Kyeng ; Yi, Sarah ; See, Isaac ; Jacob, Jesse T. ; Bower, Chris W. ; Wilson, Lucy ; Vaeth, Elisabeth ; Lynfield, Ruth ; Vagnone, Paula Snippes ; Shaw, Kristin M. ; Dumyati, Ghinwa ; Tsay, Rebecca ; Phipps, Erin C. ; Bamberg, Wendy ; Janelle, Sarah J. ; Beldavs, Zintars G. ; Cassidy, P. Maureen ; Kainer, Marion ; Muleta, Daniel ; Mounsey, Jacquelyn T. ; Laufer-Halpin, Alison ; Karlsson, Maria ; Lutgring, Joseph D. ; Walters, Maroya Spalding Less -
Description:

Background:

Carbapenem-resistant Enterobacterales (CRE) are usually healthcare-associated but are also emerging in the community.

Methods:

Active, population-based surveillance was conducted to identify case-patients with cultures positive for Enterobacterales not susceptible to a carbapenem (excluding ertapenem) and resistant to all third-generation cephalosporins tested at 8 US sites from January 2012 to December 2015. Medical records were used to classify cases as health care-associated, or as community-associated (CA) if a patient had no known health care risk factors and a culture was collected <3 days after hospital admission. Enterobacterales isolates from selected cases were submitted to CDC for whole genome sequencing.

Results:

We identified 1499 CRE cases in 1194 case-patients; 149 cases (10%) in 139 case-patients were CA. The incidence of CRE cases per 100,000 population was 2.96 (95% CI: 2.81, 3.11) overall and 0.29 (95% CI: 0.25, 0.35) for CA-CRE. Most CA-CRE cases were in White persons (73%), females (84%) and identified from urine cultures (98%). Among the 12 sequenced CA-CRE isolates, 5 (42%) harbored a carbapenemase gene.

Conclusions:

Ten percent of CRE cases were CA; some isolates from CA-CRE cases harbored carbapenemase genes. Continued CRE surveillance in the community is critical to monitor emergence outside of traditional health care settings.
Keywords:

[+]

Anti-Bacterial Agents Beta-Lactamases Carbapenemase-producing Enterobacterales Carbapenems Community-associated Disease Enterobacteriaceae Enterobacteriaceae Infections Female Healthcare-associated Infections Health Facilities Humans Microbial Sensitivity Tests Multi-drug Resistant Gram-negative Organisms Risk Factors United States
Source:

Am J Infect Control. 51(1):70-77
Pubmed ID:

35909003
Pubmed Central ID:

PMC10881240
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/
Volume:

51
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:5285e75d3f419b02d9086f11a8d6fb8845367bd4c873fcd212b699b6e8920b1a
Download URL:

https://stacks.cdc.gov/view/cdc/150311/cdc_150311_DS1.pdf
File Type:

	nihms-1963876.nxml	xml
	NIHMS1963876-supplement-Supplement.docx	docx

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