Staphylococcus aureus Regulatory RNAs as Potential Biomarkers for Bloodstream Infections
Published Date:Sep 15 2016
Source:Emerg Infect Dis. 22(9):1570-1578.
Immune Evasion Protein
Multilocus Sequence Typing
S. Aureus Protein A Typing
Second Immunoglobulin-binding Protein
Small Pathogenicity Island RNAs
Staphylococcus Aureus Regulatory RNAs As Potential Biomarkers For Bloodstream Infections
Pubmed Central ID:PMC4994353
Description:Staphylococcus aureus is a commensal bacterium and pathogen. Identifying biomarkers for the transition from colonization to disease caused by this organism would be useful. Several S. aureus small RNAs (sRNAs) regulate virulence. We investigated presence and expression of 8 sRNAs in 83 S. aureus strains from 42 patients with sepsis or septic shock and 41 asymptomatic colonized carriers. Small pathogenicity island sRNAs sprB and sprC were clade specific. Six sRNAs had variable expression not correlated with clinical status. Expression of RNAIII was lower in strains from septic shock patients than in strains from colonized patients. When RNAIII was associated with expression of sprD, colonizing strains could be discriminated from strains in patients with bloodstream infections, including patients with sepsis and septic shock. Isolates associated with colonization might have sRNAs with target expression different from those of disease isolates. Monitoring expression of RNAIII and sprD could help determine severity of bloodstream infections.
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