Staphylococcus aureus Regulatory RNAs as Potential Biomarkers for Bloodstream Infections

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bordeau, Valérie ; Cady, Anne ; Revest, Matthieu ; Rostan, Octavie ; Sassi, Mohamed ; Tattevin, Pierre ; Donnio, Pierre-Yves ; Felden, Brice
• Description:
  Staphylococcus aureus is a commensal bacterium and pathogen. Identifying biomarkers for the transition from colonization to disease caused by this organism would be useful. Several S. aureus small RNAs (sRNAs) regulate virulence. We investigated presence and expression of 8 sRNAs in 83 S. aureus strains from 42 patients with sepsis or septic shock and 41 asymptomatic colonized carriers. Small pathogenicity island sRNAs sprB and sprC were clade specific. Six sRNAs had variable expression not correlated with clinical status. Expression of RNAIII was lower in strains from septic shock patients than in strains from colonized patients. When RNAIII was associated with expression of sprD, colonizing strains could be discriminated from strains in patients with bloodstream infections, including patients with sepsis and septic shock. Isolates associated with colonization might have sRNAs with target expression different from those of disease isolates. Monitoring expression of RNAIII and sprD could help determine severity of bloodstream infections.
• Subjects:
  Bacteria Biomarkers Bloodstream Infections Immune Evasion Protein Multilocus Sequence Typing Nasal Carrier Nasal Colonization Research RNAIII S. Aureus Protein A Typing Second Immunoglobulin-binding Protein Sepsis Septic Shock Small Pathogenicity Island RNAs Small RNAs Spa Typing Spr RNAs Staphylococci Staphylococcus Aureus Staphylococcus Aureus Regulatory RNAs As Potential Biomarkers For Bloodstream Infections Transfer–messenger RNA

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• Source:
  Emerg Infect Dis. 22(9):1570-1578.
• Pubmed ID:
  27224202
• Pubmed Central ID:
  PMC4994353
• Document Type:
  Journal Article
• Volume:
  22
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a6789d6595336a24c6e86593338b7cf021a8be191f06468226233882472f4e40
• Download URL:
  https://stacks.cdc.gov/view/cdc/41245/cdc_41245_DS1.pdf
• File Type:
  [PDF - 1.57 MB ]