Newly Recognized Spotted Fever Group Rickettsia as Cause of Severe Rocky Mountain Spotted Fever–Like Illness, Northern California, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Probert, Will S. ; Haw, Monica P. ; Nichol, Aran C. ; Glaser, Carol A. ; Park, Sarah Y. ; Campbell, Laura E. ; Trivedi, Kavita K. ; Romo, Hannah ; Saunders, Megan E.M. ; Kjemtrup, Anne M. ; Padgett, Kerry A. ; Hacker, Jill K.
  More +
• Description:
  The incidence of spotted fever group (SFG) rickettsioses in the United States has tripled since 2010. Rocky Mountain spotted fever, the most severe SFG rickettsiosis, is caused by Rickettsia rickettsii. The lack of species-specific confirmatory testing obfuscates the relative contribution of R. rickettsii and other SFG Rickettsia to this increase. We report a newly recognized rickettsial pathogen, Rickettsia sp. CA6269, as the cause of severe Rocky Mountain spotted fever-like illness in 2 case-patients residing in northern California. Multilocus sequence typing supported the recognition of this pathogen as a novel Rickettsia genotype most closely related to R. rickettsii. Cross-reactivity observed for an established molecular diagnostic test indicated that Rickettsia sp. CA6269 might be misidentified as R. rickettsii. We developed a Rickettsia sp. CA6269-specific real-time PCR to help resolve this diagnostic challenge and better characterize the spectrum of clinical disease and ecologic epidemiology of this pathogen.
• Subjects:
  • Rocky Mountain Spotted Fever
  • Rickettsia
  • Male
  • Multilocus Sequence Typing
  • Phylogeny
  • Female
  • Middle Aged
  • Spotted Fever Group Rickettsiosis
  • Adult
  • Rickettsia rickettsii
• Keywords:
  • vector-borne infections
  • bacteria
  • spotted fever group Rickettsia
  • Rickettsiosis
  • Rocky Mountain spotted fever
  • ticks
  • real-time PCR
  • multilocus sequence typing
  • California
  • United States
  More +
• Source:
  Emerg Infect Dis. 2024; 30(7):1344-1351
• Pubmed ID:
  38816345
• Pubmed Central ID:
  PMC11210658
• Document Type:
  Journal Article
• Place as Subject:
  California
• Volume:
  30
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/158103/cdc_158103_DS1.pdf
• File Type:
  [PDF - 676.10 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a5960d16f13e97750b323848d19a97f8552bbf2addf89b3ee9f97f2d67fb8e5e