Human Adenovirus Associated with Severe Respiratory Infection, Oregon, USA, 2013–2014

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Scott, Magdalena Kendall ; Chommanard, Christina ; Lu, Xiaoyan ; Appelgate, Dianna ; Grenz, LaDonna ; Schneider, Eileen ; Gerber, Susan I. ; Erdman, Dean D. ; Thomas, Ann
• Description:
  Several human adenoviruses (HAdVs) can cause respiratory infections, some severe. HAdV-B7, which can cause severe respiratory disease, has not been recently reported in the United States but is reemerging in Asia. During October 2013-July 2014, Oregon health authorities identified 198 persons with respiratory symptoms and an HAdV-positive respiratory tract specimen. Among 136 (69%) hospitalized persons, 31% were admitted to the intensive care unit and 18% required mechanical ventilation; 5 patients died. Molecular typing of 109 specimens showed that most (59%) were HAdV-B7, followed by HAdVs-C1, -C2, -C5 (26%); HAdVs-B3, -B21 (15%); and HAdV-E4 (1%). Molecular analysis of 7 HAdV-B7 isolates identified the virus as genome type d, a strain previously identified only among strains circulating in Asia. Patients with HAdV-B7 were significantly more likely than those without HAdV-B7 to be adults and to have longer hospital stays. HAdV-B7 might be reemerging in the United States, and clinicians should consider HAdV in persons with severe respiratory infection.
• Subjects:
  Human Adenovirus Human Adenovirus 7 Human Adenovirus Associated With Severe Respiratory Infection, Oregon, Usa, 2013–2014 Oregon Outbreak Pneumonia Research Respiratory Infection Viruses
• Source:
  Emerg Infect Dis. 22(6):1044-1051.
• Pubmed ID:
  27191834
• Pubmed Central ID:
  PMC4880082
• Document Type:
  Journal Article
• Volume:
  22
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:26bfd62c5eac68d51eeee0338b4b692162df7ca0b0f72e430863af78fef754f5
• Download URL:
  https://stacks.cdc.gov/view/cdc/39693/cdc_39693_DS1.pdf
• File Type:
  [PDF - 1.76 MB ]