Severe Human Parainfluenza Virus Community- and Healthcare-Acquired Pneumonia in Adults at Tertiary Hospital, Seoul, South Korea, 2010–2019

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Park, Joung Ha ; Hong, Sang-Bum ; Huh, Jin Won ; Jung, Jiwon ; Kim, Min Jae ; Chong, Yong Pil ; Sung, Heungsup ; Do, Kyung Hyun ; Kim, Sung-Han ; Lee, Sang-Oh ; Kim, Yang Soo ; Lim, Chae-Man ; Koh, Younsuck ; Choi, Sang-Ho
• Description:
  The characteristics of severe human parainfluenza virus (HPIV)-associated pneumonia in adults have not been well evaluated. We investigated epidemiologic and clinical characteristics of 143 patients with severe HPIV-associated pneumonia during 2010-2019. HPIV was the most common cause (25.2%) of severe virus-associated hospital-acquired pneumonia and the third most common cause (15.7%) of severe virus-associated community-acquired pneumonia. Hematologic malignancy (35.0%), diabetes mellitus (23.8%), and structural lung disease (21.0%) were common underlying conditions. Co-infections occurred in 54.5% of patients admitted to an intensive care unit. The 90-day mortality rate for HPIV-associated pneumonia was comparable to that for severe influenza virus-associated pneumonia (55.2% vs. 48.4%; p = 0.22). Ribavirin treatment was not associated with lower mortality rates. Fungal co-infections were associated with 82.4% of deaths. Clinicians should consider the possibility of pathogenic co-infections in patients with HPIV-associated pneumonia. Contact precautions and environmental cleaning are crucial to prevent HPIV transmission in hospital settings.
• Subjects:
  Adult Aged Aged, 80 And Over Coinfection Community-Acquired Infections Cross Infection Female Healthcare-Associated Pneumonia History, 21st Century Humans Male Middle Aged Paramyxoviridae Infections Pneumonia, Viral Tertiary Care Centers Young Adult

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• Keywords:
  Human Parainfluenza Virus Immunocompromised Influenza Pneumonia Respiratory Infections Severe Pneumonia South Korea Viruses
• Source:
  Emerg Infect Dis. 2024; 30(6):1088-1095
• Pubmed ID:
  38781685
• Pubmed Central ID:
  PMC11138994
• Document Type:
  Journal Article
• Genre:
  Synopsis
• Place as Subject:
  Republic of Korea
• Volume:
  30
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4712192ffe8a04ef8edf5b8c80cb2a3fc146a8c96b17eeb3d533334a4cc8a1ac
• Download URL:
  https://stacks.cdc.gov/view/cdc/156965/cdc_156965_DS1.pdf
• File Type:
  [PDF - 942.34 KB ]