Details:

Alternative Title:
Cell Rep
Publisher's site:
http://dx.doi.org/10.1016/j.celrep.2015.11.062
Personal Author:
Jacoby, Jason ; Zhu, Yongling ; DeVries, Steven H. ; Schwartz, Gregory
Jacoby, Jason ; Zhu, Yongling ; DeVries, Steven H. ; Schwartz, Gregory Less -
Description:
Decades of research have focused on the circuit connectivity between retinal neurons, but only a handful of amacrine cells have been described functionally and placed in the context of a specific retinal circuit. Here, we identify a circuit where inhibition from a specific amacrine cell plays a vital role in shaping the feature selectivity of a postsynaptic ganglion cell. We record from transgenically labeled CRH-1 amacrine cells and identify a postsynaptic target for CRH-1 amacrine cell inhibition in an atypical retinal ganglion cell (RGC) in mouse retina, the Suppressed-by-Contrast (SbC) RGC. Unlike other RGC types, SbC RGCs spike tonically in steady illumination and are suppressed by both increases and decreases in illumination. Inhibition from GABAergic CRH-1 amacrine cells shapes this unique contrast response profile to positive contrast. We show the existence and impact of this circuit, with both paired recordings and cell-type-specific ablation.
Subject:
[+]
Amacrine Cells
Animals
Mice
Mice, Transgenic
Photic Stimulation
Retina
Retinal Ganglion Cells
Signal Transduction
Synaptic Transmission

Source:
Cell Rep. 13(12):2663-2670.
Pubmed ID:
26711334
Pubmed Central ID:
PMC4698005
Document Type:
Journal Article
Funding:
1F32EY025930-01/EY/NEI NIH HHS/United States ; DP2 EY026770/EY/NEI NIH HHS/United States ; F32 EY025930/EY/NEI NIH HHS/United States ; NIH DP2-DEY026770A/DP/NCCDPHP CDC HHS/United States ; R01 EY018204/EY/NEI NIH HHS/United States
1F32EY025930-01/EY/NEI NIH HHS/United States ; DP2 EY026770/EY/NEI NIH HHS/United States ; F32 EY025930/EY/NEI NIH HHS/United States ; NIH DP2-DEY026770A/DP/NCCDPHP CDC HHS/United States ; R01 EY018204/EY/NEI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f4c2553e6839f05aea75c8eec4a170ce2b8126451890448b6574a5f5feff5136
File Type:

Supporting Files

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