Close-Packed Silicon Microelectrodes for Scalable Spatially Oversampled Neural Recording

Scholvin, Jörg; Kinney, Justin P.; Bernstein, Jacob G.; Moore-Kochlacs, Caroline; Kopell, Nancy; Fonstad, Clifton G.; Boyden, Edward S.

doi:10.1109/TBME.2015.2406113

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Close-Packed Silicon Microelectrodes for Scalable Spatially Oversampled Neural Recording

Jan 2016
By Scholvin, Jörg ; Kinney, Justin P. ; Bernstein, Jacob G. ; ...
http://dx.doi.org/10.1109/TBME.2015.2406113
Source: IEEE Trans Biomed Eng. 63(1):120-130.

[PDF-1.99 MB]

English

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Details:

Alternative Title:

IEEE Trans Biomed Eng
Personal Author:

Scholvin, Jörg ; Kinney, Justin P. ; Bernstein, Jacob G. ; Moore-Kochlacs, Caroline ; Kopell, Nancy ; ... More +

Scholvin, Jörg ; Kinney, Justin P. ; Bernstein, Jacob G. ; Moore-Kochlacs, Caroline ; Kopell, Nancy ; Fonstad, Clifton G. ; Boyden, Edward S. Less -
Description:

Objective

Neural recording electrodes are important tools for understanding neural codes and brain dynamics. Neural electrodes that are close-packed, such as in tetrodes, enable spatial oversampling of neural activity, which facilitates data analysis. Here we present the design and implementation of close-packed silicon microelectrodes, to enable spatially oversampled recording of neural activity in a scalable fashion.

Methods

Our probes are fabricated in a hybrid lithography process, resulting in a dense array of recording sites connected to submicron dimension wiring.

Results

We demonstrate an implementation of a probe comprising 1000 electrode pads, each 9 × 9 μm, at a pitch of 11 μm. We introduce design automation and packaging methods that allow us to readily create a large variety of different designs.

Significance

Finally, we perform neural recordings with such probes in the live mammalian brain that illustrate the spatial oversampling potential of closely packed electrode sites.
Subjects:

[+]

Animals Cerebral Cortex Computer-Aided Design Equipment Design Mice Microelectrodes Neurophysiology Silicon
Source:

IEEE Trans Biomed Eng. 63(1):120-130.
Pubmed ID:

26699649
Pubmed Central ID:

PMC4692190
Document Type:

Journal Article
Funding:

R44 NS070453/NS/NINDS NIH HHS/United States ; R01 NS067199/NS/NINDS NIH HHS/United States ; R01 DA029639/DA/NIDA NIH HHS/United States ; DP1NS087724/DP/NCCDPHP CDC HHS/United States ; R01DA029639/DA/NIDA NIH HHS/United States ; ... More +

R44 NS070453/NS/NINDS NIH HHS/United States ; R01 NS067199/NS/NINDS NIH HHS/United States ; R01 DA029639/DA/NIDA NIH HHS/United States ; DP1NS087724/DP/NCCDPHP CDC HHS/United States ; R01DA029639/DA/NIDA NIH HHS/United States ; DP1 NS087724/NS/NINDS NIH HHS/United States ; R01NS067199/NS/NINDS NIH HHS/United States ; 2R44NS070453-03A1/NS/NINDS NIH HHS/United States Less -
Volume:

63
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:bdc570c21937fe62b7d290bfe1065f006c6ec3108a33b341d0de148b3a90014d
Download URL:

https://stacks.cdc.gov/view/cdc/38915/cdc_38915_DS1.pdf
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