Close-Packed Silicon Microelectrodes for Scalable Spatially Oversampled Neural Recording

Scholvin, Jörg; Kinney, Justin P.; Bernstein, Jacob G.; Moore-Kochlacs, Caroline; Kopell, Nancy; Fonstad, Clifton G.; Boyden, Edward S.

doi:10.1109/TBME.2015.2406113

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Close-Packed Silicon Microelectrodes for Scalable Spatially Oversampled Neural Recording

Published Date:

Jan 2016

Publisher's site:

http://dx.doi.org/10.1109/TBME.2015.2406113 New Site Icon

Source:

IEEE Trans Biomed Eng. 63(1):120-130.

[PDF-1.99 MB]

Details:

Personal Authors:

Scholvin, Jörg ; Kinney, Justin P. ; Bernstein, Jacob G. ; Moore-Kochlacs, Caroline ; Kopell, Nancy ; ... More ▼

Keywords:

[+]

Pubmed ID:

26699649

Pubmed Central ID:

PMC4692190

Description:

Objective

Neural recording electrodes are important tools for understanding neural codes and brain dynamics. Neural electrodes that are close-packed, such as in tetrodes, enable spatial oversampling of neural activity, which facilitates data analysis. Here we present the design and implementation of close-packed silicon microelectrodes, to enable spatially oversampled recording of neural activity in a scalable fashion.

Methods

Our probes are fabricated in a hybrid lithography process, resulting in a dense array of recording sites connected to submicron dimension wiring.

Results

We demonstrate an implementation of a probe comprising 1000 electrode pads, each 9 × 9 μm, at a pitch of 11 μm. We introduce design automation and packaging methods that allow us to readily create a large variety of different designs.

Significance

Finally, we perform neural recordings with such probes in the live mammalian brain that illustrate the spatial oversampling potential of closely packed electrode sites.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

R44 NS070453/NS/NINDS NIH HHS/United States
R01 NS067199/NS/NINDS NIH HHS/United States
R01 DA029639/DA/NIDA NIH HHS/United States
DP1NS087724/DP/NCCDPHP CDC HHS/United States
R01DA029639/DA/NIDA NIH HHS/United States
DP1 NS087724/NS/NINDS NIH HHS/United States
R01NS067199/NS/NINDS NIH HHS/United States
2R44NS070453-03A1/NS/NINDS NIH HHS/United States

Supporting Files:

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