Close-Packed Silicon Microelectrodes for Scalable Spatially Oversampled Neural Recording

Details

• Alternative Title:
  IEEE Trans Biomed Eng
• Personal Author:
  Scholvin, Jörg ; Kinney, Justin P. ; Bernstein, Jacob G. ; Moore-Kochlacs, Caroline ; Kopell, Nancy ; Fonstad, Clifton G. ; Boyden, Edward S.
• Description:
  Objective
  
  Neural recording electrodes are important tools for understanding neural codes and brain dynamics. Neural electrodes that are close-packed, such as in tetrodes, enable spatial oversampling of neural activity, which facilitates data analysis. Here we present the design and implementation of close-packed silicon microelectrodes, to enable spatially oversampled recording of neural activity in a scalable fashion.
  
  Methods
  
  Our probes are fabricated in a hybrid lithography process, resulting in a dense array of recording sites connected to submicron dimension wiring.
  
  Results
  
  We demonstrate an implementation of a probe comprising 1000 electrode pads, each 9 × 9 μm, at a pitch of 11 μm. We introduce design automation and packaging methods that allow us to readily create a large variety of different designs.
  
  Significance
  
  Finally, we perform neural recordings with such probes in the live mammalian brain that illustrate the spatial oversampling potential of closely packed electrode sites.
  
  
• Subjects:
  Animals Cerebral Cortex Computer-Aided Design Equipment Design Mice Microelectrodes Neurophysiology Silicon
• Source:
  IEEE Trans Biomed Eng. 63(1):120-130.
• Pubmed ID:
  26699649
• Pubmed Central ID:
  PMC4692190
• Document Type:
  Journal Article
• Funding:
  R44 NS070453/NS/NINDS NIH HHS/United States ; R01 NS067199/NS/NINDS NIH HHS/United States ; R01 DA029639/DA/NIDA NIH HHS/United States ; DP1NS087724/DP/NCCDPHP CDC HHS/United States ; R01DA029639/DA/NIDA NIH HHS/United States ; DP1 NS087724/NS/NINDS NIH HHS/United States ; R01NS067199/NS/NINDS NIH HHS/United States ; 2R44NS070453-03A1/NS/NINDS NIH HHS/United States
• Volume:
  63
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:bdc570c21937fe62b7d290bfe1065f006c6ec3108a33b341d0de148b3a90014d
• Download URL:
  https://stacks.cdc.gov/view/cdc/38915/cdc_38915_DS1.pdf
• File Type:
  [PDF - 1.99 MB ]