Introduction of HIV-2 and multiple HIV-1 subtypes to Lebanon.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pieniazek, Danua. ; Baggs, James. ; Hu, Dale J. ; Matar, Ghassan M. ; Abdelnoor, Alexander M. ; Mokhbat, Jacques E. ; Uwaydah, Marwan. ; Bizri, Abdul Rahman. ; Ramos, Artur. ; Janini, Luiz M. ; Tanuri, Amilcar. ; Fridlund, Carol. ; Schable, Charles. ; Heyndrickx, Leo. ; Rayfield, Mark A. ; Heneine, Walid.
• Description:
  HIV genetic variability, phylogenetic relationships, and transmission dynamics were analyzed in 26 HIV-infected patients from Lebanon. Twenty-five specimens were identified as HIV-1 and one as HIV-2 subtype B. The 25 strains were classified into six env-C2-V3 HIV-1 subtypes: B (n = 10), A (n = 11), C (n = 1), D (n = 1), G (n = 1), and unclassifiable. Potential recombinants combining parts of viral regions from different subtypes Aenv/Dpol/Agag, Genv/Apol, and the unclassifiable-subtype(env)/unclassifiable-subtype(pol)/Agag were found in three patients. Epidemiologic analysis of travel histories and behavioral risks indicated that HIV-1 and HIV-2 subtypes reflected HIV strains prevalent in countries visited by patients or their sex partners. Spread of complex HIV-subtype distribution patterns to regions where HIV is not endemic may be more common than previously thought. Blood screening for both HIV-1 and HIV-2 in Lebanon is recommended to protect the blood supply. HIV subtype data provide information for vaccine development.
• Subjects:
  Adult Base Sequence DNA, Viral Female Hiv-1 Hiv-2 Hiv Core Protein P24 Hiv Envelope Protein Gp120 Hiv Infections Hiv Protease Humans Male Middle Aged Molecular Sequence Data

  More +
• Source:
  Emerg Infect Dis. 4(4):649-656.
• Document Type:
  Journal Article
• Place as Subject:
  Lebanon
• Location:
  Asia
• Volume:
  4
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:37c297ac5c3f279fc0b11fb3e0351f139849b8f4bf3d522dc8c56e415051b5d0a248e15f473daaa65f6ed2a245037ae2277564e9ca64719560343773935b466c
• Download URL:
  https://stacks.cdc.gov/view/cdc/3750/cdc_3750_DS1.pdf
• File Type:
  [PDF - 105.25 KB ]