Air Pollution, Neighbourhood Socioeconomic Factors and Neural Tube Defects in the San Joaquin Valley of California

Details

• Alternative Title:
  Paediatr Perinat Epidemiol
• Personal Author:
  Padula, Amy M. ; Yang, Wei ; Carmichael, Suzan L. ; Tager, Ira B. ; Lurmann, Frederick ; Hammond, S. Katharine ; Shaw, Gary M.
• Description:
  Background
  
  Environmental pollutants and neighbourhood socioeconomic factors have been associated with neural tube defects, but the potential impact of interaction between ambient air pollution and neighbourhood socioeconomic factors on the risks of neural tube defects is not well understood.
  
  Methods
  
  We used data from the California Center of the National Birth Defects Study and the Children’s Health and Air Pollution Study to investigate whether associations between air pollutant exposure in early gestation and neural tube defects were modified by neighbourhood socioeconomic factors in the San Joaquin Valley of California, 1997–2006. Five pollutant exposures, three outcomes and 9 neighbourhood socioeconomic factors were included for a total of 135 investigated associations. Estimates were adjusted for maternal race-ethnicity, education and multivitamin use.
  
  Results
  
  We present below odds ratios that exclude 1 and a chi-square test of homogeneity p-value of <0.05. We observed increased odds of spina bifida comparing the highest to lowest quartile of particulate matter <10 micrometres (PM10) among those living in a neighbourhood with: a) median household income of less than $30,000 per year (OR 5.1, 95% CI 1.7, 15.3); b) more than 20% living below the federal poverty level (OR 2.6, 95% CI 1.1, 6.0); and c) more than 30% with less than or equal to a high school education (OR 3.2, 95% CI 1.4, 7.4). The ORs were not statistically significant among those higher SES neighbourhoods.
  
  Conclusions
  
  Our results demonstrate effect modification by neighbourhood socioeconomic factors in the association of particulate matter and neural tube defects in California.
  
  
• Subjects:
  Adolescent Air Pollutants Article Carbon Monoxide Child Environmental Exposure Female Humans Infant, Newborn Male Maternal Exposure Neural Tube Defects Nitrogen Oxides Ozone Particulate Matter Population Surveillance Pregnancy Prenatal Exposure Delayed Effects Residence Characteristics Socioeconomic Factors Vehicle Emissions

  More +
• Source:
  Paediatr Perinat Epidemiol. 29(6):536-545.
• Pubmed ID:
  26443985
• Pubmed Central ID:
  PMC4646169
• Document Type:
  Journal Article
• Funding:
  K99 ES021470/ES/NIEHS NIH HHS/United States ; U50/CCU913241/PHS HHS/United States ; U01 DD001033/DD/NCBDD CDC HHS/United States ; L40 ES023163/ES/NIEHS NIH HHS/United States ; P01 ES022849/ES/NIEHS NIH HHS/United States ; P20 ES018173/ES/NIEHS NIH HHS/United States
• Place as Subject:
  California
• Volume:
  29
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:559e177a169d26192bad70d50dfd5db12a6c2ce291772f6ed7770d22840c6f0c
• Download URL:
  https://stacks.cdc.gov/view/cdc/36492/cdc_36492_DS1.pdf
• File Type:
  [PDF - 329.34 KB ]