Maternal periconceptional exposure to drinking water disinfection by-products and neural tube defects in offspring

Kancherla, V.; Rhoads, A.; Conway, K. M.; Suhl, J.; Langlois, P. H.; Hoyt, A. T.; Shaw, G. M.; Evans, S. P.; Moore, C. A.; Luben, T. J.; Michalski, A.; Feldkamp, M. L.; Romitti, P. A.

doi:10.1002/bdr2.2370

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Maternal periconceptional exposure to drinking water disinfection by-products and neural tube defects in offspring

6 2024
By Kancherla, V. ; Rhoads, A. ; Conway, K. M. ; ...
http://dx.doi.org/10.1002/bdr2.2370
Source: Birth Defects Res. 116(6):e2370

[PDF-306.64 KB]

English

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Details:

Alternative Title:

Birth Defects Res
Personal Author:

Kancherla, V. ; Rhoads, A. ; Conway, K. M. ; Suhl, J. ; Langlois, P. H. ; ... More +

Kancherla, V. ; Rhoads, A. ; Conway, K. M. ; Suhl, J. ; Langlois, P. H. ; Hoyt, A. T. ; Shaw, G. M. ; Evans, S. P. ; Moore, C. A. ; Luben, T. J. ; Michalski, A. ; Feldkamp, M. L. ; Romitti, P. A. Less -
Corporate Authors:

National Birth Defects Prevention Study
Description:

Background:

Associations between maternal periconceptional exposure to disinfection by-products (DBPs) in drinking water and neural tube defects (NTDs) in offspring are inconclusive, limited in part by exposure misclassification.

Methods:

Maternal interview reports of drinking water sources and consumption from the National Birth Defects Prevention Study were linked with DBP concentrations in public water system monitoring data for case children with an NTD and control children delivered during 2000–2005. DBPs analyzed were total trihalomethanes, the five most common haloacetic acids combined, and individual species. Associations were estimated for all NTDs combined and selected subtypes (spina bifida, anencephaly) with maternal periconceptional exposure to DBPs in public water systems and with average daily periconceptional ingestion of DBPs accounting for individual-level consumption and filtration information. Mixed effects logistic regression models with maternal race/ethnicity and educational attainment at delivery as fixed effects and study site as a random intercept were applied.

Results:

Overall, 111 case and 649 control children were eligible for analyses. Adjusted odds ratios for maternal exposure to DBPs in public water systems ranged from 0.8–1.5 for all NTDs combined, 0.6–2.0 for spina bifida, and 0.7–1.9 for anencephaly; respective ranges for average daily maternal ingestion of DBPs were 0.7–1.1, 0.5–1.5, and 0.6–1.8. Several positive estimates (≥1.2) were observed, but all confidence intervals included the null.

Conclusions:

Using community- and individual-level data from a large, US, population-based, case–control study, we observed statistically nonsignificant associations between maternal periconceptional exposure to total and individual DBP species in drinking water and NTDs and subtypes.
Subjects:

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Adult Case-Control Studies Disinfectants Disinfection Drinking Water Female Humans Male Maternal Exposure Neural Tube Defects Pregnancy Prenatal Exposure Delayed Effects Spinal Dysraphism Trihalomethanes Water Pollutants, Chemical Water Purification
Keywords:

[+]

Anencephaly Drinking Water Haloacetic Acides Neural Tube Defects Pregnancy Spina Bifida Trihalomethanes
Source:

Birth Defects Res. 116(6):e2370
Pubmed ID:

38888449
Pubmed Central ID:

PMC11295258
Document Type:

Journal Article
Funding:

U01 DD001223/DD/NCBDD CDC HHSUnited States/ ; U01 DD001307/DD/NCBDD CDC HHSUnited States/ ; U01DD001223/CC/CDC HHSUnited States/ ; FOA #DD09-001/CC/CDC HHSUnited States/ ; FOA #DD13-003/CC/CDC HHSUnited States/ ; ... More +

U01 DD001223/DD/NCBDD CDC HHSUnited States/ ; U01 DD001307/DD/NCBDD CDC HHSUnited States/ ; U01DD001223/CC/CDC HHSUnited States/ ; FOA #DD09-001/CC/CDC HHSUnited States/ ; FOA #DD13-003/CC/CDC HHSUnited States/ ; U01 DD001035/DD/NCBDD CDC HHSUnited States/ ; U01DD001035/CC/CDC HHSUnited States/ ; PA #96043/CC/CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; PA #02081/CC/CDC HHSUnited States/ ; NOFO #DD18-001/CC/CDC HHSUnited States/ ; U01DD001307/CC/CDC HHSUnited States/ Less -
Volume:

116
Issue:

6
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:238abe75970c6f306bd5f47b539cc70663cce9f9ff39e2a334bece8e9ef94c8dd59cb26b44c6fc5f6d019a4d1c05955feb9e21008a7fe0e96908f8b22dbccfc2
Download URL:

https://stacks.cdc.gov/view/cdc/159543/cdc_159543_DS1.pdf
File Type:

	nihms-2009472-f0001.gif	gif
	nihms-2009472-f0001.jpg	jpeg
	nihms-2009472.nxml	xml
	NIHMS2009472-supplement-Supplementary_material.docx	docx

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