Arterial Stiffness, Oxidative Stress, and Smoke Exposure in Wildland Firefighters
Published Date:Jun 06 2014
Source:Am J Ind Med. 57(7):748-756.
Air Pollutants, Occupational
Pulse Wave Analysis
Pubmed Central ID:PMC4629844
Funding:CC999999/Intramural CDC HHS/United States
To assess the association between exposure, oxidative stress, symptoms, and cardiorespiratory function in wildland firefighters.
We studied two Interagency Hotshot Crews with questionnaires, pulse wave analysis for arterial stiffness, spirometry, urinary 8-iso-prostaglandin F2α (8-isoprostane) and 8-hydroxy-2′-deoxyguanosine (8-OHdG), and the smoke exposure marker (urinary levoglucosan). Arterial stiffness was assessed by examining levels of the aortic augmentation index, expressed as a percentage. An oxidative stress score comprising the average of z-scores created for 8-OHdG and 8-isoprostane was calculated.
Mean augmentation index % was higher for participants with higher oxidative stress scores after adjusting for smoking status. Specifically for every one unit increase in oxidative stress score the augmentation index % increased 10.5% (95% CI: 2.5, 18.5%). Higher mean lower respiratory symptom score was associated with lower percent predicted forced expiratory volume in one second/forced vital capacity.
Biomarkers of oxidative stress may serve as indicators of arterial stiffness in wildland firefighters.
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