Arterial Stiffness, Oxidative Stress, and Smoke Exposure in Wildland Firefighters

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Gaughan, Denise M. ; Siegel, Paul D. ; Hughes, Michael D. ; Chang, Chiung-Yu ; Law, Brandon F. ; Campbell, Corey R. ; Richards, Jennifer C. ; Kales, Stefanos F. ; Chertok, Marcia ; Kobzik, Lester ; Nguyen, Phuongson ; O’Donnell, Carl R. ; Kiefer, Max ; Wagner, Gregory R. ; Christiani, David C.
• Description:
  Objectives
  
  To assess the association between exposure, oxidative stress, symptoms, and cardiorespiratory function in wildland firefighters.
  
  Methods
  
  We studied two Interagency Hotshot Crews with questionnaires, pulse wave analysis for arterial stiffness, spirometry, urinary 8-iso-prostaglandin F2α (8-isoprostane) and 8-hydroxy-2′-deoxyguanosine (8-OHdG), and the smoke exposure marker (urinary levoglucosan). Arterial stiffness was assessed by examining levels of the aortic augmentation index, expressed as a percentage. An oxidative stress score comprising the average of z-scores created for 8-OHdG and 8-isoprostane was calculated.
  
  Results
  
  Mean augmentation index % was higher for participants with higher oxidative stress scores after adjusting for smoking status. Specifically for every one unit increase in oxidative stress score the augmentation index % increased 10.5% (95% CI: 2.5, 18.5%). Higher mean lower respiratory symptom score was associated with lower percent predicted forced expiratory volume in one second/forced vital capacity.
  
  Conclusions
  
  Biomarkers of oxidative stress may serve as indicators of arterial stiffness in wildland firefighters.
  
  
• Subjects:
  8-hydroxy-2′-deoxyguanosine 8-iso-prostaglandin F2α Adult Air Pollutants, Occupational Article Biological Markers Cross-Sectional Studies Firefighters Health Surveys Humans Levoglucosan Male Multivariate Analysis Occupational Exposure Oxidative Stress Pulse Wave Analysis Questionnaires Smoke Spirometry Vascular Stiffness

  More +
• Source:
  Am J Ind Med. 57(7):748-756.
• Pubmed ID:
  24909863
• Pubmed Central ID:
  PMC4629844
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  57
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4804c00b62103bed5129123e834e3b5d106887375808d63fb44ee4a08d5b7917
• Download URL:
  https://stacks.cdc.gov/view/cdc/36381/cdc_36381_DS1.pdf
• File Type:
  [PDF - 196.52 KB ]