Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters

Details

• Personal Author:
  Campbell CR ; Chang C-Y ; Chertok M ; Christiani, David C. ; Gaughan, Denise M. ; Hughes MD ; Kales SF ; Kiefer, Max ; Kobzik L ; Law, Brandon F. ; Nguyen P-S ; O'Donnell CR ; Richards JC ; Siegel, Paul D. ; Wagner, Gregory R.
• Description:
  Objectives: To assess the association between exposure, oxidative stress, symptoms, and cardiorespiratory function in wildland firefighters. Methods: We studied two Interagency Hotshot Crews with questionnaires, pulse wave analysis for arterial stiffness, spirometry, urinary 8-iso-prostaglandin F2a (8-isoprostane) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), and the smoke exposure marker (urinary levoglucosan). Arterial stiffness was assessed by examining levels of the aortic augmentation index, expressed as a percentage. An oxidative stress score comprising the average of z-scores created for 8-OHdG and 8-isoprostane was calculated. Results: Mean augmentation index % was higher for participants with higher oxidative stress scores after adjusting for smoking status. Specifically for every one unit increase in oxidative stress score the augmentation index % increased 10.5% (95% CI: 2.5, 18.5%). Higher mean lower respiratory symptom score was associated with lower percent predicted forced expiratory volume in one second/forced vital capacity. Conclusions: Biomarkers of oxidative stress may serve as indicators of arterial stiffness in wildland firefighters. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cardiovascular System Firefighters Men Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smoke Surveys And Questionnaires Women

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• Keywords:
  8-hydroxy-2'-deoxyguanosine 8-iso-prostaglandin F2a Author Keywords: Vascular Stiffness Cardiopulmonary-function Cardiopulmonary-system Exposure-levels Fire-fighters Humans Levoglucosan Questionnaires Respiration Respiratory-function-tests Respiratory-rate Respiratory-system-disorders Risk-factors Smoke-inhalation Spirometry Stress

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 8 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; WSO - Western States Office
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  57
• Issue:
  7
• NIOSHTIC Number:
  nn:20044475
• Citation:
  Am J Ind Med 2014 Jul; 57(7):748-756
• Contact Point Address:
  DeniseM.Gaughan, ScD, Icahn School of Medicine at Mount Sinai, 17 East 102nd Street, D3-132, NewYork , NY 10029-6574
• Email:
  denise.gaughan@mssm.edu
• Federal Fiscal Year:
  2014
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:153db142c1975d397c18c16f14fd720e6b25c86b1643e8abb1977b14fe49758ffbca1959cf49d8ecd94e3608249237b789396680df62fcf2d35006ea777132ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/200165/cdc_200165_DS1.pdf
• File Type:
  [PDF - 135.58 KB ]