Arterial stiffness in adolescents and young adults with and without type 1 diabetes: the SEARCH CVD study

Details

• Alternative Title:
  Pediatr Diabetes
• Personal Author:
  Shah, Amy S. ; Wadwa, R. Paul ; Dabelea, Dana ; Hamman, Richard F. ; D’Agostino, Ralph ; Marcovina, Santica ; Daniels, Stephen R. ; Dolan, Lawrence M. ; Fino, Nora F. ; Urbina, Elaine M.
• Description:
  Background
  
  Arterial stiffness is a useful parameter to predict future cardiovascular disease.
  
  Objective
  
  We sought to compare arterial stiffness in adolescents and young adults with and without type 1 diabetes (T1D) and explore the risk factors associated with the differences observed.
  
  Subjects and methods
  
  Carotid-femoral pulse wave velocity (PWV), augmentation index (AI75), and brachial distensibility (BrachD) were measured in 402 adolescents and young adults with T1D (age 18.8 ± 3.3 yr, T1D duration 9.8 ± 3.8 yr) and 206 non-diabetic controls that were frequency-matched by age, sex, and race/ethnicity in a cross-sectional study. General linear models were used to explore variables associated with an increase in arterial stiffness after adjustment for demographic and metabolic covariates.
  
  Results
  
  T1D status was associated with a higher PWV (5.9 ± 0.05 vs. 5.7 ± 0.1 m/s), AI75 (1.3 ± 0.6 vs. −1.9 ± 0.7%), and lower BrachD (6.2 ± 0.1 vs. 6.5 ± 0.1%Δ/mmHg), all p < 0.05. In multivariate models, age, sex, race, adiposity, blood pressure, lipids, and the presence of microalbuminuria were found to be independent correlates of increased arterial stiffness. After adjustment for these risk factors, T1D status was still significantly associated with arterial stiffness (p < 0.05).
  
  Conclusions
  
  Peripheral and central subclinical vascular changes are present in adolescents and young adults with T1D compared to controls. Increased cardiovascular risk factors alone do not explain the observed differences in arterial stiffness among cases and controls. Identifying other risk factors associated with increased arterial stiffness in youth with T1D is critical to prevent future vascular complications.
  
  
• Subjects:
  Adolescent Adult Ankle Brachial Index Cardiovascular Diseases Case-Control Studies Cross-Sectional Studies Diabetes Mellitus, Type 1 Diabetic Angiopathies Female Humans Male Pulse Wave Analysis Vascular Stiffness Young Adult

  More +
• Source:
  Pediatr Diabetes. 16(5):367-374
• Pubmed ID:
  25912292
• Pubmed Central ID:
  PMC4712021
• Document Type:
  Journal Article
• Funding:
  U18 DP006134/DP/NCCDPHP CDC HHSUnited States/ ; R01DK078542/DK/NIDDK NIH HHSUnited States/ ; UL1 TR001425/TR/NCATS NIH HHSUnited States/ ; R01 DK078542/DK/NIDDK NIH HHSUnited States/ ; K23 HL118132/HL/NHLBI NIH HHSUnited States/ ; K23HL118132/HL/NHLBI NIH HHSUnited States/
• Place as Subject:
  Colorado ; Ohio
• Volume:
  16
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ff460b59426776cfacbc47f3b8686714e8e0c96052ab083492430ad92fdcdbce
• Download URL:
  https://stacks.cdc.gov/view/cdc/112540/cdc_112540_DS1.pdf
• File Type:
  [PDF - 148.76 KB ]