Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Logan, Latania K. ; Renschler, John P. ; Gandra, Sumanth ; Weinstein, Robert A. ; Laxminarayan, Ramanan
Logan, Latania K. ; Renschler, John P. ; Gandra, Sumanth ; Weinstein, Robert A. ; Laxminarayan, Ramanan Less -
Corporate Authors:
for the Centers for Disease Control ; Prevention Epicenters Program
for the Centers for Disease Control ; Prevention Epicenters Program Less -
Description:
The prevalence of carbapenem-resistant Enterobacteriaceae (CRE) infections is increasing in the United States. However, few studies have addressed their epidemiology in children. To phenotypically identify CRE isolates cultured from patients 1-17 years of age, we used antimicrobial susceptibilities of Enterobacteriaceae reported to 300 laboratories participating in The Surveillance Network-USA database during January 1999-July 2012. Of 316,253 isolates analyzed, 266 (0.08%) were identified as CRE. CRE infection rate increases were highest for Enterobacter species, blood culture isolates, and isolates from intensive care units, increasing from 0.0% in 1999-2000 to 5.2%, 4.5%, and 3.2%, respectively, in 2011-2012. CRE occurrence in children is increasing but remains low and is less common than that for extended-spectrum β-lactamase-producing Enterobacteriaceae. The molecular characterization of CRE isolates from children and clinical epidemiology of infection are essential for development of effective prevention strategies.
Subject:
[+]
Adolescent
Anti-Bacterial Agents
Carbapenem-Resistant Enterobacteriaceae
Carbapenems
Child
Child, Preschool
Cross Infection
Enterobacteriaceae
Enterobacteriaceae Infections
Humans
Infant
Intensive Care Units
Prevalence
Research

Source:
Emerg Infect Dis. 21(11):2014-2021
Pubmed ID:
26486124
Pubmed Central ID:
PMC4622248
Document Type:
Journal Article
Funding:
K08 AI112506/AI/NIAID NIH HHS/United States ; 5K08AI112506-02/AI/NIAID NIH HHS/United States
K08 AI112506/AI/NIAID NIH HHS/United States ; 5K08AI112506-02/AI/NIAID NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:171515d2cdfb7440a46c9fb986da522c34946abdea3826d017547d60043d5c51
File Type:

Supporting Files

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