Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Aizawa, Yuta ; Watanabe, Kanako ; Oishi, Tomohiro ; Hirano, Harunobu ; Hasegawa, Isao ; ... More +
Aizawa, Yuta ; Watanabe, Kanako ; Oishi, Tomohiro ; Hirano, Harunobu ; Hasegawa, Isao ; Saitoh, Akihiko Less -
Description:
Human parechovirus type 3 (HPeV3) is an emerging pathogen that causes sepsis and meningoencephalitis in young infants. To test the hypothesis that maternal antibodies can protect this population, we measured neutralizing antibody titers (NATs) to HPeV3 and other genotypes (HPeV1 and HPeV6) in 175 cord blood samples in Japan. The seropositivity rate (≥1:32) for HPeV3 was 61%, similar to that for the other genotypes, but decreased significantly as maternal age increased (p<0.001). Furthermore, during the 2014 HPeV3 epidemic, prospective measurement of NATs to HPeV3 in 45 patients with severe diseases caused by HPeV3 infection showed low NATs (≤1:16) at onset and persistently high NATs (≥1:512) until age 6 months. All intravenous immunoglobulin samples tested elicited high NATs to HPeV3. Our findings indicate that maternal antibodies to HPeV3 may help protect young infants from severe diseases related to HPeV3 and that antibody supplementation may benefit these patients.
Subjects:
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Child, Preschool Female Genotype Humans Infant Infant, Newborn Male Parechovirus Picornaviridae Infections Prospective Studies Research RNA, Viral Role Of Maternal Antibodies In Infants With Severe Diseases Related To Human Parechovirus Type 3
Source:
Emerg Infect Dis. 21(11):1966-1972
Pubmed ID:
26485714
Pubmed Central ID:
PMC4622238
Document Type:
Journal Article
Place as Subject:
Japan
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:93748639627d600ab53e36a9050d56d90cd878c854694b2ed636083ca7a8f1d0
Download URL:
https://stacks.cdc.gov/view/cdc/35532/cdc_35532_DS1.pdf
File Type:

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