Chest radiographic features of human metapneumovirus infection in pediatric patients

Details

• Alternative Title:
  Pediatr Radiol
• Personal Author:
  Hilmes, Melissa A. ; Dunnavant, F. Daniel ; Singh, Sudha P. ; Ellis, Wendy D. ; Payne, Daniel C. ; Zhu, Yuwei ; Griffin, Marie R. ; Edwards, Kathryn M. ; Williams, John V.
• Description:
  Background ; Human metapneumovirus (HMPV) was identified in 2001 and is a common cause of acute respiratory illness in young children. The radiologic characteristics of laboratory-confirmed HMPV acute respiratory illness in young children have not been systematically assessed. ; Objective ; We systematically evaluated the radiographic characteristics of acute respiratory illness associated with HMPV in a prospective cohort of pediatric patients. ; Materials and methods ; We included chest radiographs from children <5 years old with acute respiratory illness who were enrolled in the prospective New Vaccine Surveillance Network (NVSN) study from 2003 to 2009 and were diagnosed with HMPV by reverse transcription-polymerase chain reaction (RT-PCR). Of 215 HMPV-positive subjects enrolled at our tertiary care children’s hospital, 68 had chest radiographs obtained by the treating clinician that were available for review. Two fellowship-trained pediatric radiologists, independently and then in consensus, retrospectively evaluated these chest radiographs for their radiographic features. ; Results ; Parahilar opacities were the most commonly observed abnormality, occurring in 87% of children with HMPV. Hyperinflation also occurred frequently (69%). Atelectasis (40%) and consolidation (18%) appeared less frequently. Pleural effusion and pneumothorax were not seen on any radiographs. ; Conclusion ; The clinical presentations of HMPV include bronchiolitis, croup and pneumonia. Dominant chest radiographic abnormalities include parahilar opacities and hyperinflation, with occasional consolidation. Recognition of the imaging patterns seen with common viral illnesses like respiratory syncytial virus (RSV) and HMPV might facilitate diagnosis and limit unnecessary antibiotic treatment.
• Keywords:
  • Bronchiolitis
  • Chest
  • Children
  • Human metapneumovirus
  • Infection
  • Lungs
  • Radiography
  • Respiratory tract
  • Acute Disease
  • Child, Preschool
  More +
• Source:
  Pediatr Radiol. 47(13):1745-1750
• Pubmed ID:
  28831577
• Pubmed Central ID:
  PMC5901753
• Document Type:
  Journal Article
• Funding:
  U01 IP000022/Centers for Disease Control and Prevention/ ; R01 AI085062/AI/NIAID NIH HHSUnited States/ ; AI-085062/Foundation for the National Institutes of Health/ ; U38 CCU417958/Centers for Disease Control and Prevention/ ; U01 IP000022/IP/NCIRD CDC HHSUnited States/
• Volume:
  47
• Issue:
  13
• Download URL:
  https://stacks.cdc.gov/view/cdc/53504/cdc_53504_DS1.pdf
• File Type:
  [PDF - 1.77 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:04d3fb5dbde85e21a001a2b68362ec8c135ff47edb758b6306dfb427b53ffd37