Welcome to CDC stacks | Child Mortality Levels and Trends by HIV Status in Blantyre, Malawi: 1989-2009 - 33436 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Child Mortality Levels and Trends by HIV Status in Blantyre, Malawi: 1989-2009
Filetype[PDF-66.61 KB]


Details:
  • Pubmed ID:
    22692091
  • Pubmed Central ID:
    PMC3458133
  • Description:
    Introduction

    Continuous evaluation of child survival is needed in sub-Saharan Africa where HIV prevalence among women of reproductive age continues to be high. We examined mortality levels and trends over a period of ~20 years among HIV-unexposed and exposed children in Blantyre, Malawi.

    Methods

    Data from five prospective cohort studies conducted at a single research site from 1989-2009 were analyzed. In these studies, children born to HIV-infected and uninfected mothers were enrolled at birth and followed longitudinally for at least two years. Information on socio-demographic, HIV infection status, survival and associated risk factors was collected in all studies. Mortality rates were estimated using birth-cohort analyses stratified by maternal and infant HIV status. Multivariate Cox regression models were used to determine risk factors associated with mortality.

    Results

    The analysis included 8,286 children. From 1989-1995, overall mortality rates (per 100 person-years) in these clinic-based cohorts remained comparable among HIV-uninfected children born to HIV-uninfected mothers (range 3.3-6.9) or to HIV-infected mothers (range 2.5-7.5). From 1989-2009, overall mortality remained high among all children born to HIV-infected mothers (range 6.3-19.3), and among children who themselves became infected (range 15.6-57.4, 1994-2009). Only lower birth weight was consistently and significantly (P<0.05) associated with higher child mortality.

    Conclusions

    HIV infection among mothers and children contributed to high levels of child mortality in the African setting in the pre-treatment era. In addition to services that prevent mother-to-child transmission of HIV, other programs are needed to improve child survival by lowering HIV-unrelated mortality through innovative interventions that strengthen health infrastructure.

  • Document Type:
  • Collection(s):
  • Funding:
    5-U50-PS022061-05/PS/NCHHSTP CDC HHS/United States
    5R03TW01199/TW/FIC NIH HHS/United States
    N01 AI035173/AI/NIAID NIH HHS/United States
    N01 CP033005/CP/NCI NIH HHS/United States
    N01-AI-35173-117/AI/NIAID NIH HHS/United States
    N01-CP-33005/CP/NCI NIH HHS/United States
    P01 AI026499/AI/NIAID NIH HHS/United States
    P01-AI-26499/AI/NIAID NIH HHS/United States
    R03 TW001199/TW/FIC NIH HHS/United States
    R21-AI-33874-01/AI/NIAID NIH HHS/United States
    U50-CC0222061/CC/ODCDC CDC HHS/United States
No Related Documents.
You May Also Like: