Details:

Alternative Title:
AIDS Behav
Publisher's site:
http://dx.doi.org/10.1007/s10461-014-0891-z
Personal Author:
Kebaabetswe, Poloko M. ; Stirratt, Michael J. ; McLellan-Lemal, Eleanor ; Henderson, Faith L. ; Gray, Simone C. ; ... More +
Kebaabetswe, Poloko M. ; Stirratt, Michael J. ; McLellan-Lemal, Eleanor ; Henderson, Faith L. ; Gray, Simone C. ; Rose, Charles E. ; Williams, Tiffany ; Paxton, Lynn A. Less -
Description:
This study examined study product adherence and its determinants in the Botswana oral pre-exposure prophylaxis efficacy trial. Among the 1,219 participants, the mean adherence by pill count and 3-day self-report was 94 % for each. In multivariable models, pill count adherence was significantly associated with adverse events (nausea, dizziness, vomiting) (RR 0.98 95 % CI 0.98-1.00; p = 0.03) and side effect concerns (RR 0.98 95 % CI 0.96-0.99; p = 0.01). Self-reported adherence was significantly associated with having an HIV-positive partner (RR 1.02 95 % CI 1.00-1.04; p = 0.02) and Francistown residence (RR 0.98 95 % CI 0.96, 0.99; p = 0.0001). Detectable drug concentrations showed modest associations with self-report and pill count adherence, and drug levels were higher among those self-reporting 100 % adherence than those reporting <100 %. Most common adherence barriers involved refill delays and other logistic challenges; cellphone alarm reminder use was the most common facilitator.
Subjects:
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Adherence Administration, Oral Adult Anti-HIV Agents Article Emtricitabine Female HIV Infections HIV Prevention Humans Logistic Models Male Medication Adherence Multivariate Analysis Oral Pre-exposure Prophylaxis (PrEP) Pre-Exposure Prophylaxis Self Report Surveys And Questionnaires Tenofovir
Source:
AIDS Behav. 19(5):758-769.
Pubmed ID:
25186785
Pubmed Central ID:
PMC4586059
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Botswana
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1216cc3e64561424ceea42c059ab7af88cdf59e43d93430cd9de5e083fcbad60
Download URL:
https://stacks.cdc.gov/view/cdc/34535/cdc_34535_DS1.pdf
File Type:

Supporting Files

• 	NIHMS718511-supplement-S1.docx	docx
  	nihms718511.nxml	bin

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