Factors Associated with Adherence and Concordance Between Measurement Strategies in an HIV Daily Oral Tenofovir/Emtricitabine as Pre-exposure Prophylaxis (PreP) Clinical Trial, Botswana, 2007-2010

Details

• Alternative Title:
  AIDS Behav
• Personal Author:
  Kebaabetswe, Poloko M. ; Stirratt, Michael J. ; McLellan-Lemal, Eleanor ; Henderson, Faith L. ; Gray, Simone C. ; Rose, Charles E. ; Williams, Tiffany ; Paxton, Lynn A.
• Description:
  This study examined study product adherence and its determinants in the Botswana oral pre-exposure prophylaxis efficacy trial. Among the 1,219 participants, the mean adherence by pill count and 3-day self-report was 94 % for each. In multivariable models, pill count adherence was significantly associated with adverse events (nausea, dizziness, vomiting) (RR 0.98 95 % CI 0.98-1.00; p = 0.03) and side effect concerns (RR 0.98 95 % CI 0.96-0.99; p = 0.01). Self-reported adherence was significantly associated with having an HIV-positive partner (RR 1.02 95 % CI 1.00-1.04; p = 0.02) and Francistown residence (RR 0.98 95 % CI 0.96, 0.99; p = 0.0001). Detectable drug concentrations showed modest associations with self-report and pill count adherence, and drug levels were higher among those self-reporting 100 % adherence than those reporting <100 %. Most common adherence barriers involved refill delays and other logistic challenges; cellphone alarm reminder use was the most common facilitator.
• Subjects:
  Adherence Administration, Oral Adult Anti-HIV Agents Article Emtricitabine Female HIV Infections HIV Prevention Humans Logistic Models Male Medication Adherence Multivariate Analysis Oral Pre-exposure Prophylaxis (PrEP) Pre-Exposure Prophylaxis Self Report Surveys And Questionnaires Tenofovir

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• Source:
  AIDS Behav. 19(5):758-769.
• Pubmed ID:
  25186785
• Pubmed Central ID:
  PMC4586059
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  Botswana
• Volume:
  19
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1216cc3e64561424ceea42c059ab7af88cdf59e43d93430cd9de5e083fcbad60
• Download URL:
  https://stacks.cdc.gov/view/cdc/34535/cdc_34535_DS1.pdf
• File Type:
  [PDF - 306.01 KB ]