Protective effects of low calcium intake and low calcium absorption vitamin D receptor genotype in the California Collaborative Prostate Cancer Study

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Rowland, Glovioell W. ; Schwartz, Gary G. ; John, Esther M. ; Ingles, Sue Ann
• Description:
  Background
  
  High calcium intake is consistently associated with increased prostate cancer risk in epidemiologic studies. We previously reported that the positive association between calcium intake and risk of aggressive prostate cancer was modified by the Vitamin D Receptor (VDR) calcium absorption genotype, Cdx2, among African American men.
  
  Methods
  
  We expanded our previous study to include White men, a population with a higher calcium intake and a higher prevalence of the low absorption allele. We also examined VDR polymorphisms at other loci unrelated to calcium absorption. The study included 1,857 prostate cancer cases (1,140 with advanced stage at diagnosis, 717 with localized stage) and 1,096 controls. Odds ratios (OR) were estimated using conditional logistic regression.
  
  Results
  
  Among both Blacks and Whites, we observed a threshold for calcium intake (604 mg/day) below which prostate cancer risk declined sharply. Low calcium intake was most strongly associated with decreased risk among men with the VDR Cdx2 low calcium absorption genotype (p for interaction = 0.001 and p=0.06 for Whites and African Americans, respectively). Among all men with this genotype, those in the lowest quartile of calcium intake (<=604 mg/day) had a 50% reduction in risk compared to those in the upper three quartiles (OR=0.49, 95% CI=0.36–0.67). The association between calcium intake and prostate cancer risk was not modified by genotype at other VDR loci.
  
  Conclusions and Impact
  
  Our findings support the hypothesis that genetic determinants of calcium absorption influence prostate cancer risk and may contribute to racial disparities in prostate cancer incidence and mortality rates.
  
  
• Subjects:
  Aged Age Distribution Alleles Black Or African American Calcium, Dietary Case-Control Studies Confidence Intervals Dose-Response Relationship, Drug Genotype Humans Logistic Models Male Middle Aged Odds Ratio Polymorphism, Single Nucleotide Prevalence Prognosis Prostatic Neoplasms Receptors, Calcitriol Reference Values Retrospective Studies Risk Assessment Survival Rate White People

  More +
• Keywords:
  Calcium Absorption Ethnicity Genetic Polymorphism Prostate Cancer Vitamin D Receptor
• Source:
  Cancer Epidemiol Biomarkers Prev. 22(1):16-24
• Pubmed ID:
  23129590
• Pubmed Central ID:
  PMC3763955
• Document Type:
  Journal Article
• Funding:
  R01 CA084979/CA/NCI NIH HHSUnited States/ ; T32 CA009492/CA/NCI NIH HHSUnited States/ ; N01-PC-35139/PC/NCI NIH HHSUnited States/ ; 1U58DP000807-3/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP000807/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35139/CA/NCI NIH HHSUnited States/ ; N01PC35136/CA/NCI NIH HHSUnited States/ ; T32-CA009492/CA/NCI NIH HHSUnited States/ ; N01-PC-35136/PC/NCI NIH HHSUnited States/ ; R01CA84979/CA/NCI NIH HHSUnited States/
• Place as Subject:
  California
• Volume:
  22
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5d6e443da306deb4e48be474688ac840c8752ab59c014949a5f0fee8bc7b09b9
• Download URL:
  https://stacks.cdc.gov/view/cdc/33623/cdc_33623_DS1.pdf
• File Type:
  [PDF - 78.81 KB ]