Calcium Intake and Prostate Cancer Among African Americans: Effect Modification by Vitamin D Receptor Calcium Absorption Genotype

Details

• Alternative Title:
  J Bone Miner Res
• Personal Author:
  Rowland, Glovioell W. ; Schwartz, Gary G. ; John, Esther M. ; Ingles, Sue Ann
• Description:
  High dietary intake of calcium has been classified as a probable cause of prostate cancer, although the mechanism underlying the association between dietary calcium and prostate cancer risk is unclear. The vitamin D receptor (VDR) is a key regulator of calcium absorption. In the small intestine, VDR expression is regulated by the CDX-2 transcription factor, which binds a polymorphic site in the VDR gene promoter. We examined VDR Cdx2 genotype and calcium intake, assessed by a food frequency questionnaire, in 533 African-American prostate cancer cases (256 with advanced stage at diagnosis, 277 with localized stage) and 250 African-American controls who participated in the California Collaborative Prostate Cancer Study. We examined the effects of genotype, calcium intake, and diet-gene interactions by conditional logistic regression. Compared with men in the lowest quartile of calcium intake, men in the highest quartile had an approximately twofold increased risk of localized and advanced prostate cancer (odds ratio [OR] = 2.20, 95% confidence interval [CI] = 1.40, 3.46), with a significant dose-response. Poor absorbers of calcium (VDR Cdx2 GG genotype) had a significantly lower risk of advanced prostate cancer (OR = 0.41, 95% CI = 0.19, 0.90). The gene-calcium interaction was statistically significant (p = 0.03). Among men with calcium intake below the median (680 mg/day), carriers of the G allele had an approximately 50% decreased risk compared with men with the AA genotype. These findings suggest a link between prostate cancer risk and high intestinal absorption of calcium.
• Subjects:
  Aged Aged, 80 And Over Black Or African American Calcium Calcium, Dietary Case-Control Studies CDX2 Transcription Factor Dietary Supplements Homeodomain Proteins Humans Intestinal Absorption Male Middle Aged Obesity Polymorphism, Genetic Prostatic Neoplasms Receptors, Calcitriol Risk Factors

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• Keywords:
  African American Calcium Absorption Genetic Polymorphism Prostate Cancer Vitamin D Receptor
• Source:
  J Bone Miner Res. 27(1):187-194
• Pubmed ID:
  21887707
• Pubmed Central ID:
  PMC3234334
• Document Type:
  Journal Article
• Funding:
  R01 CA084979/CA/NCI NIH HHSUnited States/ ; R01 CA084979-01/CA/NCI NIH HHSUnited States/ ; N01-PC-35139/PC/NCI NIH HHSUnited States/ ; 1U58DP000807-3/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP000807/DP/NCCDPHP CDC HHSUnited States/ ; T32 ES013678/ES/NIEHS NIH HHSUnited States/ ; T32-ES013678/ES/NIEHS NIH HHSUnited States/ ; N01PC35136/CA/NCI NIH HHSUnited States/ ; N01PC35139/CA/NCI NIH HHSUnited States/ ; N01-PC-35136/PC/NCI NIH HHSUnited States/ ; R01CA84979/CA/NCI NIH HHSUnited States/
• Volume:
  27
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:55b886851e1928d7b61ca40d95876c2ddadd9a7651ba134a35da8409b430ee71
• Download URL:
  https://stacks.cdc.gov/view/cdc/33280/cdc_33280_DS1.pdf
• File Type:
  [PDF - 65.89 KB ]