Details:

Alternative Title:
Clin Infect Dis
Publisher's site:
http://dx.doi.org/10.1093/cid/ciu680
Personal Author:
McLean, Huong Q. ; Thompson, Mark G. ; Sundaram, Maria E. ; Meece, Jennifer K. ; McClure, David L. ; ... More +
McLean, Huong Q. ; Thompson, Mark G. ; Sundaram, Maria E. ; Meece, Jennifer K. ; McClure, David L. ; Friedrich, Thomas C. ; Belongia, Edward A. Less -
Description:
Recent studies suggest that influenza vaccination in the previous season may influence the effectiveness of current-season vaccination, but this has not been assessed in a single population over multiple years.|Patients presenting with acute respiratory illness were prospectively enrolled during the 2004-2005 through 2012-2013 influenza seasons. Respiratory swabs were tested for influenza and vaccination dates obtained from a validated registry. Vaccination status was determined for the current, previous, and prior 5 seasons. Vaccine effectiveness (VE) was calculated for participants aged ≥9 years using logistic regression models with an interaction term for vaccination history.|There were 7315 enrollments during 8 seasons; 1056 (14%) and 650 (9%) were positive for influenza A(H3N2) and B, respectively. Vaccination during current only, previous only, or both seasons yielded similar protection against H3N2 (adjusted VE range, 31%-36%) and B (52%-66%). In the analysis using 5 years of historical vaccination data, current season VE against H3N2 was significantly higher among vaccinated individuals with no prior vaccination history (65%; 95% confidence interval [CI], 36%-80%) compared with vaccinated individuals with a frequent vaccination history (24%; 95% CI, 3%-41%; P = .01). VE against B was 75% (95% CI, 50%-87%) and 48% (95% CI, 29%-62%), respectively (P = .05). Similar findings were observed when analysis was restricted to adults 18-49 years.|Current- and previous-season vaccination generated similar levels of protection, and vaccine-induced protection was greatest for individuals not vaccinated during the prior 5 years. Additional studies are needed to understand the long-term effects of annual vaccination.
Subject:
[+]
Adolescent
Adult
Aged
Aged, 80 And Over
Articles And Commentaries
Child
Comorbidity
Female
Humans
Immunization, Secondary
Influenza
Influenza, Human
Influenza A Virus, H3N2 Subtype
Influenza B Virus
Influenza Vaccines
Male
Middle Aged
Outcome Assessment (Health Care)
Risk Factors
Seasons
Vaccination
Vaccine Effectiveness
Young Adult

Source:
Clin Infect Dis. 2014; 59(10):1375-1385.
Pubmed ID:
25270645
Pubmed Central ID:
PMC4207422
Document Type:
Journal Article
Funding:
U01 IP000471/IP/NCIRD CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5b86aba92eb9082db0810eece053902c47582844fde019d01f11a7a1a75314be
File Type:

Supporting Files

• 	supp_59_10_1375__index.html	htm
  	supp_ciu680_ciu680supp_figures.docx	docx
  	supp_ciu680_ciu680supp_table1.docx	docx
  	ciu680.nxml	txt
  	ciu68001.gif	gif
  	ciu68001.jpg	jpeg
  	ciu68002.gif	gif
  	ciu68002.jpg	jpeg
  	license.txt	txt

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