Maternal intake of vitamin E and birth defects, National Birth Defects Prevention Study, 1997–2005
Published Date:Apr 17 2014
Source:Birth Defects Res A Clin Mol Teratol. 100(9):647-657.
Corporate Authors:National Birth Defects Prevention Study
Congenital Heart Defects
Heart Defects, Congenital
Prenatal Exposure Delayed Effects
Pubmed Central ID:PMC4465220
Funding:DK56350/DK/NIDDK NIH HHS/United States
SUZ0/Intramural CDC HHS/United States
In a recent study, high maternal periconceptional intake of vitamin E was found to be associated with risk of congenital heart defects (CHDs). To explore this association further, we investigated the association between total daily vitamin E intake and selected birth defects.
We analyzed data from 4,525 controls and 8,665 cases from the 1997–2005 National Birth Defects Prevention Study. We categorized estimated periconceptional energy-adjusted total daily vitamin E intake from diet and supplements into quartiles (referent, lowest quartile). Associations between quartiles of energy-adjusted vitamin E intake and selected birth defects were adjusted for demographic, lifestyle, and nutritional factors.
We observed a statistically significant association with the third quartile of vitamin E intake (OR 1.17; 95% CI 1.01 – 1.35) and all CHDs combined. Among CHD sub-types, we observed associations with left ventricular outflow tract obstruction defects, and its sub-type, coarctation of the aorta and the third quartile of vitamin E intake. Among defects other than CHDs, we observed associations between anorectal atresia and the third quartile of vitamin E intake (OR 1.66; 95% CI 1.01 – 2.72) and hypospadias and the fourth quartile of vitamin E intake (OR 1.42; 95% CI 1.09 – 1.87).
Selected quartiles of energy-adjusted estimated total daily vitamin E intake were associated with selected birth defects. However, because these few associations did not exhibit exposure-response patterns consistent with increasing risk associated with increasing intake of vitamin E, further studies are warranted to corroborate our findings.
application/vnd.openxmlformats-officedocument.wordprocessingml.document text/plain image/gif image/jpeg
You May Also Like: