Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Congenital Heart Defects among Offspring in the National Birth Defects Prevention Study

Lupo, Philip J.; Symanski, Elaine; Langlois, Peter H.; Lawson, Christina C.; Malik, Sadia; Gilboa, Suzanne M.; Lee, Laura J.; Agopian, A. J.; Desrosiers, Tania A.; Waters, Martha A.; Romitti, Paul A.; Correa, Adolfo; Shaw, Gary M.; Mitchell, Laura E.

doi:10.1002/bdra.23071

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Congenital Heart Defects among Offspring in the National Birth Defects Prevention Study

11 2012
By Lupo, Philip J. ; Symanski, Elaine ; Langlois, Peter H. ; ...
http://dx.doi.org/10.1002/bdra.23071
Source: Birth Defects Res A Clin Mol Teratol. 94(11):875-881

[PDF-213.61 KB]

English

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Details:

Alternative Title:

Birth Defects Res A Clin Mol Teratol
Personal Author:

Lupo, Philip J. ; Symanski, Elaine ; Langlois, Peter H. ; Lawson, Christina C. ; Malik, Sadia ; ... More +

Lupo, Philip J. ; Symanski, Elaine ; Langlois, Peter H. ; Lawson, Christina C. ; Malik, Sadia ; Gilboa, Suzanne M. ; Lee, Laura J. ; Agopian, A. J. ; Desrosiers, Tania A. ; Waters, Martha A. ; Romitti, Paul A. ; Correa, Adolfo ; Shaw, Gary M. ; Mitchell, Laura E. Less -
Description:

BACKGROUND

There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring.

METHODS

Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring.

RESULTS

The prevalence of occupational PAH exposure was 4.0% in CHD case mothers (76/1907) and 3.6% in control mothers (104/2853). After adjusting for maternal age, race or ethnicity, education, smoking, folic acid supplementation, and study center, exposure was not associated with conotruncal defects (adjusted odds ratio [AOR], 0.98; 95% confidence interval [CI], 0.58–1.67), septal defects (AOR, 1.28; 95% CI, 0.86–1.90), or with any isolated CHD subtype.

CONCLUSIONS

Our findings do not support an association between potential maternal occupational exposure to PAHs and various CHDs in a large, population-based study. For CHD phenotypic subtypes in which modest nonsignificant associations were observed, future investigations could be improved by studying populations with a higher prevalence of PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism.
Subjects:

[+]

Adult Case-Control Studies Female Health Surveys Heart Defects, Congenital Humans Infant Logistic Models Male Maternal Exposure Occupational Exposure Odds Ratio Polycyclic Aromatic Hydrocarbons Pregnancy Prenatal Exposure Delayed Effects Prevalence Risk Factors United States
Keywords:

[+]

Birth Defects Congenital Heart Defects Epidemiology Maternal Occupation Polycyclic Aromatic Hydrocarbons
Source:

Birth Defects Res A Clin Mol Teratol. 94(11):875-881
Pubmed ID:

22945317
Pubmed Central ID:

PMC4552186
Document Type:

Journal Article
Funding:

FOA DD09-001/DD/NCBDD CDC HHSUnited States/ ; U01DD000494/DD/NCBDD CDC HHSUnited States/ ; U01 DD000494/DD/NCBDD CDC HHSUnited States/ ; PA 02081/PHS HHSUnited States/ ; PA 96043/PHS HHSUnited States/ ; ... More +

FOA DD09-001/DD/NCBDD CDC HHSUnited States/ ; U01DD000494/DD/NCBDD CDC HHSUnited States/ ; U01 DD000494/DD/NCBDD CDC HHSUnited States/ ; PA 02081/PHS HHSUnited States/ ; PA 96043/PHS HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ Less -
Volume:

94
Issue:

11
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:350d9a71862d4c70ebb326b536c9d7309d4a6e8118a71cd28ffe028c12f90a93
Download URL:

https://stacks.cdc.gov/view/cdc/33921/cdc_33921_DS1.pdf
File Type:

nihms717572.nxml

xml

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