Acquired Drug Resistance in Mycobacterium tuberculosis and Poor Outcomes among Patients with Multidrug-Resistant Tuberculosis

Kempker, Russell R.; Kipiani, Maia; Mirtskhulava, Veriko; Tukvadze, Nestani; Magee, Matthew J.; Blumberg, Henry M.

doi:10.3201/eid2106.141873

i

Acquired Drug Resistance in Mycobacterium tuberculosis and Poor Outcomes among Patients with Multidrug-Resistant Tuberculosis

Supporting Files

Jun 2015
By Kempker, Russell R. ; Kipiani, Maia ; Mirtskhulava, Veriko ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Kempker, Russell R. ; Kipiani, Maia ; Mirtskhulava, Veriko ; Tukvadze, Nestani ; Magee, Matthew J. ; Blumberg, Henry M.
Description:

Rates and risk factors for acquired drug resistance and association with outcomes among patients with multidrug-resistant tuberculosis (MDR TB) are not well defined. In an MDR TB cohort from the country of Georgia, drug susceptibility testing for second-line drugs (SLDs) was performed at baseline and every third month. Acquired resistance was defined as any SLD whose status changed from susceptible at baseline to resistant at follow-up. Among 141 patients, acquired resistance in Mycobacterium tuberculosis was observed in 19 (14%); prevalence was 9.1% for ofloxacin and 9.8% for capreomycin or kanamycin. Baseline cavitary disease and resistance to >6 drugs were associated with acquired resistance. Patients with M. tuberculosis that had acquired resistance were at significantly increased risk for poor treatment outcome compared with patients without these isolates (89% vs. 36%; p<0.01). Acquired resistance occurs commonly among patients with MDR TB and impedes successful treatment outcomes.
Subjects:

Acquired Drug Resistance Acquired Drug Resistance In Mycobacterum Tuberculosis And Poor Outcomes Among Patients With Multdrug-Resistant Tuberculosis Antimicrobial Resistance Bacteria CME Extensively Drug-resistant Tuberculosis MDR TB Multidrug-resistant Tuberculosis Multidrug Resistance Mycobacterium Tuberculosis Research Treatment Outcomes Tuberculosis And Other Mycobacteria XDR TB
Source:

Emerg Infect Dis. 21(6):992-1001.
Document Type:

Journal Article
Funding:

D43TW007124/TW/FIC NIH HHS/United States ; K23AI103044/AI/NIAID NIH HHS/United States ; UL1TR000454/TR/NCATS NIH HHS/United States
Volume:

21
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:11f966db5fee97b4a49a0ea17ae1038d8c401cc06cfd4e95e1ec4e65f6501aba
Download URL:

https://stacks.cdc.gov/view/cdc/31539/cdc_31539_DS1.pdf
File Type:

[PDF - 1.21 MB ]

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