Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2106.141873
Personal Author:
Kempker, Russell R. ; Kipiani, Maia ; Mirtskhulava, Veriko ; Tukvadze, Nestani ; Magee, Matthew J. ; ... More +
Kempker, Russell R. ; Kipiani, Maia ; Mirtskhulava, Veriko ; Tukvadze, Nestani ; Magee, Matthew J. ; Blumberg, Henry M. Less -
Description:
Rates and risk factors for acquired drug resistance and association with outcomes among patients with multidrug-resistant tuberculosis (MDR TB) are not well defined. In an MDR TB cohort from the country of Georgia, drug susceptibility testing for second-line drugs (SLDs) was performed at baseline and every third month. Acquired resistance was defined as any SLD whose status changed from susceptible at baseline to resistant at follow-up. Among 141 patients, acquired resistance in Mycobacterium tuberculosis was observed in 19 (14%); prevalence was 9.1% for ofloxacin and 9.8% for capreomycin or kanamycin. Baseline cavitary disease and resistance to >6 drugs were associated with acquired resistance. Patients with M. tuberculosis that had acquired resistance were at significantly increased risk for poor treatment outcome compared with patients without these isolates (89% vs. 36%; p<0.01). Acquired resistance occurs commonly among patients with MDR TB and impedes successful treatment outcomes.
Subject:
[+]
Acquired Drug Resistance
Acquired Drug Resistance In Mycobacterum Tuberculosis And Poor Outcomes Among Patients With Multdrug-Resistant Tuberculosis
Antimicrobial Resistance
Bacteria
CME
Extensively Drug-resistant Tuberculosis
MDR TB
Multidrug-resistant Tuberculosis
Multidrug Resistance
Mycobacterium Tuberculosis
Research
Treatment Outcomes
Tuberculosis And Other Mycobacteria
XDR TB

Source:
Emerg Infect Dis. 21(6):992-1001.
Document Type:
Journal Article
Funding:
D43TW007124/TW/FIC NIH HHS/United States ; K23AI103044/AI/NIAID NIH HHS/United States ; UL1TR000454/TR/NCATS NIH HHS/United States
D43TW007124/TW/FIC NIH HHS/United States ; K23AI103044/AI/NIAID NIH HHS/United States ; UL1TR000454/TR/NCATS NIH HHS/United States Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:11f966db5fee97b4a49a0ea17ae1038d8c401cc06cfd4e95e1ec4e65f6501aba
File Type:

Supporting Files

• 	14-1873-F1.gif	gif
  	14-1873-F1.jpg	jpeg
  	14-1873-F2.gif	gif
  	14-1873-F2.jpg	jpeg
  	14-1873.nxml	txt
  	license.txt	txt

More +