Treatment Outcomes for Patients with Extensively Drug-Resistant Tuberculosis, KwaZulu-Natal and Eastern Cape Provinces, South Africa

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Kvasnovsky, Charlotte L. ; Cegielski, J. Peter ; van der Walt, Martie L.
• Description:
  We analyzed data for a retrospective cohort of patients treated for extensively drug-resistant tuberculosis in 2 provinces in South Africa and compared predictors of treatment outcome in HIV-positive patients who received or had not received antiretroviral drugs with those for HIV-negative patients. Overall, 220 (62.0%) of 355 patients were HIV positive. After 2 years, 34 (10.3%) of 330 patients with a known HIV status and known outcome had a favorable outcome. Multivariate analysis showed that predictors of favorable outcome were negative results for acid-fast bacilli by sputum microscopy at start of treatment and weight >50 kg. HIV-positive patients were more likely to have an unfavorable outcome. The strongest predictor of unfavorable outcome was weight <50 kg. Overall outcomes were poor. HIV status was not a predictor of favorable outcome, but HIV-positive patients were more likely to have an unfavorable outcome. These results underscore the need for timely and adequate treatment for tuberculosis and HIV infection.
• Subjects:
  Antimicrobial Resistance Bacteria Epidemiology Extensively Drug-Resistant Tuberculosis Hiv/Aids Synopsis Treatment Outcomes Tuberculosis And Other Mycobacteria Xdr Tb
• Source:
  Emerg Infect Dis. 22(9):1529-1536.
• Pubmed ID:
  27538119
• Pubmed Central ID:
  PMC4994366
• Document Type:
  Journal Article
• Place as Subject:
  South Africa
• Location:
  Africa
• Volume:
  22
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0c3f0a4f94c72e9e4851ebd2534ab0f8ff312ec2bcc208eb386b0416307b904d
• Download URL:
  https://stacks.cdc.gov/view/cdc/41255/cdc_41255_DS1.pdf
• File Type:
  [PDF - 581.50 KB ]