Cost-effectiveness of Chlamydia Vaccination Programs for Young Women

Owusu-Edusei, Kwame; Chesson, Harrell W.; Gift, Thomas L.; Brunham, Robert C.; Bolan, Gail

doi:10.3201/eid2106.141270

i

Cost-effectiveness of Chlamydia Vaccination Programs for Young Women

Supporting Files Public Domain

Jun 2015
By Owusu-Edusei, Kwame ; Chesson, Harrell W. ; Gift, Thomas L. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Owusu-Edusei, Kwame ; Chesson, Harrell W. ; Gift, Thomas L. ; Brunham, Robert C. ; Bolan, Gail
Description:

We explored potential cost-effectiveness of a chlamydia vaccine for young women in the United States by using a compartmental heterosexual transmission model. We tracked health outcomes (acute infections and sequelae measured in quality-adjusted life-years [QALYs]) and determined incremental cost-effectiveness ratios (ICERs) over a 50-year analytic horizon. We assessed vaccination of 14-year-old girls and catch-up vaccination for 15-24-year-old women in the context of an existing chlamydia screening program and assumed 2 prevaccination prevalences of 3.2% by main analysis and 3.7% by additional analysis. Estimated ICERs of vaccinating 14-year-old girls were $35,300/QALY by main analysis and $16,200/QALY by additional analysis compared with only screening. Catch-up vaccination for 15-24-year-old women resulted in estimated ICERs of $53,200/QALY by main analysis and $26,300/QALY by additional analysis. The ICER was most sensitive to prevaccination prevalence for women, followed by cost of vaccination, duration of vaccine-conferred immunity, and vaccine efficacy. Our results suggest that a successful chlamydia vaccine could be cost-effective.
Subjects:

Adolescent Adult Bacterial Vaccines Chlamydia Infections Cost-Benefit Analysis Female Humans Models, Theoretical Outcome Assessment, Health Care Population Surveillance Prevalence Quality-Adjusted Life Years Vaccination Young Adult
Source:

Emerg Infect Dis. 21(6):960-968.
Document Type:

Journal Article
Place as Subject:

United States
Volume:

21
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:6d6553e994bfab3387e0a16820fee41bc38782278d74d94628e21892bbad1b21
Download URL:

https://stacks.cdc.gov/view/cdc/31528/cdc_31528_DS1.pdf
File Type:

[PDF - 1.19 MB ]

File Language:

English

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