Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

van der Linden, J.W.M.; Arendrup, M.C.; Warris, A.; Lagrou, K.; Pelloux, H.; Hauser, P.M.; Chryssanthou, E.; Mellado, E.; Kidd, S.E.; Tortorano, A.M.; Dannaoui, E.; Gaustad, P.; Baddley, J.W.; Uekötter, A.; Lass-Flörl, C.; Klimko, N.; Moore, C.B.; Denning, D.W.; Pasqualotto, A.C.; Kibbler, C.; Arikan-Akdagli, S.; Andes, D.; Meletiadis, J.; Naumiuk, L.; Nucci, M.; Melchers, W.J.G.; Verweij, P.E.

doi:10.3201/eid2106.140717

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Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

Published Date:

Jun 2015

Publisher's site:

http://dx.doi.org/10.3201/eid2106.140717 New Site Icon

Source:

Emerg Infect Dis. 21(6):1041-1044.

[PDF - 816.13 KB]

Details:

Personal Authors:

van der Linden, J.W.M. ; Arendrup, M.C. ; Warris, A. ; Lagrou, K. ; Pelloux, H. ; ... More ▼

Keywords:

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Description:

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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