Harnessing the Antiinflammatory Power of MyD88 to Reduce Allergic Fungal Inflammation?

Details

• Personal Author:
  Gaurav R ; Poole JA
• Description:
  In summary, this study provides mechanistic insights into the role of TLR2 and MyD88 signaling in reducing allergenic responses, particularly with exposure to A. fumigatus. The novel findings in this paper will pave the way for a better understanding of the antiinflammatory driving mechanisms following TLR/MyD88 signaling in DCs to potentially lead to the development of targeted therapies to reduce fungal-driven allergic diseases such as allergic bronchopulmonary aspergillosis and allergic airway inflammation. [Description provided by NIOSH]
• Subjects:
  Fungi Hypersensitivity Immune System Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Allergic Reactions Aspergillosis Aspergillus Infection Fungal Diseases Immune Reaction Respiratory Diseases
• ISSN:
  1044-1549
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-3
• Volume:
  64
• Issue:
  1
• NIOSHTIC Number:
  nn:20061383
• Citation:
  Am J Respir Cell Mol Biol 2021 Jan; 64(1):1-3
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  False
• Start Date:
  20110901
• Source Full Name:
  American Journal of Respiratory Cell and Molecular Biology
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3dc807cd465a4d51a8f24b1edeca3ce13058ad4c4445c30e84f9fe7ce86aa6a9b2e6271e81fbd440395ab7d63a5ea51ad208bd64915c8cd8e92764dca46c64bd
• Download URL:
  https://stacks.cdc.gov/view/cdc/224924/cdc_224924_DS1.pdf
• File Type:
  [PDF - 568.33 KB ]