Environmental Hotspots for Azole Resistance Selection of Aspergillus fumigatus, the Netherlands

Schoustra, Sijmen E.; Debets, Alfons J.M.; Rijs, Antonius J.M.M.; Zhang, Jianhua; Snelders, Eveline; Leendertse, Peter C.; Melchers, Willem J.G.; Rietveld, Anton G.; Zwaan, Bas J.; Verweij, Paul E.

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Environmental Hotspots for Azole Resistance Selection of Aspergillus fumigatus, the Netherlands

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Jul 2019
By Schoustra, Sijmen E. ; Debets, Alfons J.M. ; Rijs, Antonius J.M.M. ; ...

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English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Schoustra, Sijmen E. ; Debets, Alfons J.M. ; Rijs, Antonius J.M.M. ; Zhang, Jianhua ; Snelders, Eveline ; Leendertse, Peter C. ; Melchers, Willem J.G. ; Rietveld, Anton G. ; Zwaan, Bas J. ; Verweij, Paul E.
Description:

Azole resistance is a major concern for treatment of infections with Aspergillus fumigatus. Environmental resistance selection is a main route for Aspergillus spp. to acquire azole resistance. We investigated the presence of environmental hotspots for resistance selection in the Netherlands on the basis of the ability of A. fumigatus to grow and reproduce in the presence of azole fungicide residues. We identified 3 hotspots: flower bulb waste, green waste material, and wood chippings. We recovered azole-resistant A. fumigatus from these sites; all fungi contained cyp51A tandem repeat-mediated resistance mechanisms identical to those found in clinical isolates. Tebuconazole, epoxiconazole, and prothioconazole were the most frequently found fungicide residues. Stockpiles of plant waste contained the highest levels of azole-resistant A. fumigatus, and active aerobic composting reduced Aspergillus colony counts. Preventing plant waste stockpiling or creating unfavorable conditions for A. fumigatus to grow in stockpiles might reduce environmental resistance burden.
Subjects:

Antimicrobial Resistance Aspergillosis Aspergillus Fumigatus Azole Resistance Environmental Hotspots Environmental Hotspots For Azole Resistance Selection Of Aspergillus Fumigatus, The Netherlands Exposure Fungal Infections Fungi Fungicide Research Selection The Netherlands
Source:

Emerg Infect Dis. 25(7):1347-1353
Pubmed ID:

31211684
Pubmed Central ID:

PMC6590754
Document Type:

Journal Article
Volume:

25
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:5a9ba7870397d3d9880b02e5073bbcbc1a5d7f818e919b0e517e79cb6b2892b4
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https://stacks.cdc.gov/view/cdc/79629/cdc_79629_DS1.pdf
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[PDF - 450.49 KB ]

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