Invasive Group A Streptococcal Disease: Risk Factors for Adults

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Factor, Stephanie H. ; Levine, Orin S. ; Schwartz, Benjamin ; Harrison, Lee H. ; Farley, Monica M. ; McGeer, Allison ; Schuchat, Anne
• Description:
  We conducted a case-control study to identify risk factors for invasive group A streptococcal (GAS) infections, which can be fatal. Case-patients were identified when Streptococcus pyogenes was isolated from a normally sterile site and control subjects (two or more) were identified and matched to case-patients by using sequential-digit telephone dialing. All participants were noninstitutionalized surveillance area residents, >18 years of age. Conditional logistic regression identified the risk factors for invasive GAS infection: in adults 18 to 44 years of age, exposure to one or more children with sore throats (relative risk RR=4.93, p=0.02), HIV infection (RR=15.01, p=0.04), and history of injecting drug use (RR=14.71, p=0.003); in adults >45 years of age, number of persons in the home (RR=2.68, p=0.004), diabetes (RR=2.27, p=0.03), cardiac disease (RR=3.24, p=0.006), cancer (RR=3.54, p=0.006), and corticosteroid use (RR=5.18, p=0.03). Thus, host and environmental factors increased the risk for invasive GAS disease.
• Subjects:
  • Research
  • Streptococcus pyogenes
  • group A streptococcal disease, invasive disease, risk factors, case-control, sequential-digit dialing
  • necrotizing fasciitis, streptococcal toxic shock syndrome, conditional logistic regression, research
  • Adult
  • Aged
  • Case-Control Studies
  • Child
  • Environmental Exposure
  • Female
  More +
• Source:
  Emerg Infect Dis. 9(8):970-977
• Pubmed ID:
  12967496
• Pubmed Central ID:
  PMC3020599
• Document Type:
  Journal Article
• Volume:
  9
• Issue:
  8
• Download URL:
  https://stacks.cdc.gov/view/cdc/3142/cdc_3142_DS1.pdf
• File Type:
  [PDF - 278.90 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:8bcc5873b28e3a366da60779c079988a07a811fe31325ab5fe174ae0995a15f4c8cf239379d561cd969f4a26d9b55537a4a188fb6306496c92c1a17f1386bbaa