MAPK genes interact with diet and lifestyle factors to alter risk of breast cancer: The Breast Cancer Health Disparities Study

Details

• Alternative Title:
  Nutr Cancer
• Personal Author:
  Slattery, Martha L. ; Lundgreen, Abbie ; John, Esther M. ; Torres-Mejia, Gabriela ; Hines, Lisa ; Giuliano, Anna R. ; Baumgartner, Kathy B. ; Stern, Mariana C. ; Wolff, Roger K.
• Description:
  Mitogen-activated protein kinases (MAPK) are integration points for multiple biochemical signals. We evaluated 13 MAPK genes with breast cancer risk and determined if diet and lifestyle factors mediated risk. Data from 3 population-based case-control studies conducted in Southwestern United States, California, and Mexico included 4183 controls and 3592 cases. Percent Indigenous American (IA) ancestry was determined from 104 ancestry informative markers. The adaptive rank truncated product (ARTP) was used to determine the significance of each gene and the pathway with breast cancer risk, by menopausal status, genetic ancestry level, and estrogen receptor (ER)/progesterone receptor (PR) strata. MAP3K9 was associated with breast cancer overall (P(ARTP) = 0.02) with strongest association among women with the highest IA ancestry (P(ARTP) = 0.04). Several SNPs in MAP3K9 were associated with ER+/PR+ tumors and interacted with dietary oxidative balance score (DOBS), dietary folate, body mass index (BMI), alcohol consumption, cigarette smoking, and a history of diabetes. DUSP4 and MAPK8 interacted with calories to alter breast cancer risk; MAPK1 interacted with DOBS, dietary fiber, folate, and BMI; MAP3K2 interacted with dietary fat; and MAPK14 interacted with dietary folate and BMI. The patterns of association across diet and lifestyle factors with similar biological properties for the same SNPs within genes provide support for associations.
• Subjects:
  Adult Aged Body Mass Index Breast Neoplasms Case-Control Studies Diet Dietary Fats Dietary Fiber Dual-Specificity Phosphatases Energy Intake Female Folic Acid Health Status Disparities Humans Life Style MAP Kinase Kinase Kinases Menopause Middle Aged Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 14 Mitogen-Activated Protein Kinase Phosphatases Mitogen-Activated Protein Kinases Polymorphism, Single Nucleotide Population Groups Receptors, Estrogen Receptors, Progesterone Registries Risk Factors San Francisco

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• Source:
  Nutr Cancer. 67(2):292-304.
• Pubmed ID:
  25629224
• Pubmed Central ID:
  PMC4450722
• Document Type:
  Journal Article
• Funding:
  1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; CA078552/CA/NCI NIH HHS/United States ; CA078682/CA/NCI NIH HHS/United States ; CA078762/CA/NCI NIH HHS/United States ; CA078802/CA/NCI NIH HHS/United States ; CA14002/CA/NCI NIH HHS/United States ; CA63446/CA/NCI NIH HHS/United States ; CA77305/CA/NCI NIH HHS/United States ; HHSN261201000036C/PHS HHS/United States ; N01-PC-67000/PC/NCI NIH HHS/United States ; R01 CA078682/CA/NCI NIH HHS/United States ; R01 CA140002/CA/NCI NIH HHS/United States ; R25 CA174664/CA/NCI NIH HHS/United States
• Place as Subject:
  Mexico ; Southwestern United States
• Volume:
  67
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e7ee1a60f077d71c79baa9b769d721ff354dfb5d358a505dd5b1ae9e6c0f65db
• Download URL:
  https://stacks.cdc.gov/view/cdc/31391/cdc_31391_DS1.pdf
• File Type:
  [PDF - 849.58 KB ]