Key Determinants of the Fungal and Bacterial Microbiomes in Homes

Details

• Alternative Title:
  Environ Res
• Personal Author:
  Kettleson, Eric M. ; Adhikari, Atin ; Vesper, Stephen ; Chatterjee, Kanistha ; Indugula, Reshmi ; Reponen, Tiina
• Description:
  Backgroundy ; The microbiome of the home is of great interest because of its possible impact on health. Our goal was to identify some of the factors that determine the richness, evenness and diversity of the home's fungal and bacterial microbiomes. ; Methods ; Vacuumed settled dust from homes (n=35) in Cincinnati, OH, were analyzed by pyrosequencing to determine the fungal and bacterial relative sequence occurrence. The correlation coefficients between home environmental characteristics, including age of home, Environmental Relative Moldiness Index (ERMI) values, occupant number, relative humidity and temperature, as well as pets (dog and cat) were evaluated for their influence on fungal and bacterial communities. In addition, linear discriminant analysis (LDA) was used for identifying fungal and bacterial genera and species associated with those housing determinants found to be significant. ; Results ; The fungal richness was found to be positively correlated with age of home (p=0.002), ERMI value (p=0.003), and relative humidity (p=0.015) in the home. However, fungal evenness and diversity were only correlated with the age of home (p=0.001). Diversity and evenness (not richness) of the bacterial microbiome in the homes were associated with dog ownership. ; Conclusions ; Some key determinants of the fungal and bacterial microbiome appear to be excess moisture, age of the home and dog ownership.
• Subjects:
  • Air Microbiology
  • Animals
  • Asthma
  • Bacteria
  • Cats
  • Cohort Studies
  • DNA, Bacterial
  • DNA, Fungal
  • DNA, Ribosomal Spacer
  • Dogs
  More +
• Keywords:
  • indoor environment
  • microbial diversity
  • bacteria
  • fungi
  • microbiome
• Source:
  Environ Res. 2015; 138:130-135
• Pubmed ID:
  25707017
• Pubmed Central ID:
  PMC4385485
• Document Type:
  Journal Article
• Funding:
  R01 ES011170/ES/NIEHS NIH HHSUnited States/ ; T32 ES010957/ES/NIEHS NIH HHSUnited States/ ; T42 OH008432/OH/NIOSH CDC HHSUnited States/ ; T42OH008432-07/OH/NIOSH CDC HHSUnited States/ ; T32ES010957-11/ES/NIEHS NIH HHSUnited States/ ; ES11170/ES/NIEHS NIH HHSUnited States/ ; UL1 TR001425/TR/NCATS NIH HHSUnited States/
• Volume:
  138
• Download URL:
  https://stacks.cdc.gov/view/cdc/31238/cdc_31238_DS1.pdf
• File Type:
  [PDF - 461.21 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0e6e37002841296332ffcebe1f18cdedc96c267fff00e7f8e6e1333f8905df60