Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies

Zhu, Yong; Romitti, Paul A.; Conway, Kristin M. Caspers; Kim, Sunkyung; Zhang, Ying; Yang, Michele; Mathews, Katherine D.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies

Published Date:

Jun 03 2015

Source:

Muscle Nerve. 52(1):22-27.

Language:

English

[PDF-227.87 KB]

Details:

Personal Authors:

Zhu, Yong ; Romitti, Paul A. ; Conway, Kristin M. Caspers ; Kim, Sunkyung ; Zhang, Ying ; ... More ▼

Corporate Authors:

MD STARnet

Keywords:

[+]

Pubmed ID:

25297835

Pubmed Central ID:

PMC4412791

Description:

Introduction

Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data.

Methods

Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, hazard ratios (HR) and 95% confidence intervals (CI) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early-versus late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids).

Results

Among the 918 males, 81 (9%) had a GU condition; voiding dysfunction (n=40), GU tract infection (n=19), and kidney/ureter calculus (n=9) were most common. A Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR=2.7, 95% CI=1.3-5.6).

Discussion

These findings highlight increased awareness of GU health and multidisciplinary care of DBMD patients.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States
U01 DD000831/DD/NCBDD CDC HHS/United States
U01 DD001119/DD/NCBDD CDC HHS/United States
UL1 TR001108/TR/NCATS NIH HHS/United States

Supporting Files:

	nihms-682902-f0001.gif	image/gif
	nihms-682902-f0001.jpg	image/jpeg
	nihms-682902.nxml	text/xml

No Related Documents.

You May Also Like:

Secondary conditions among males with Duchenne or Becker muscular dystrophy

Personal Author:

Latimer, Rebecca; Street, Natalie; Conway, Kristin Caspers; James, Kathy; Cunniff, Christopher; Oleszek, Joyce; Fox, Deborah; Ciafaloni, Emma; Westfield, Christina; Paramsothy, Pangaja;

Corporate Author:

Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STAR

Published:

Apr 09 2017

Source:

J Child Neurol. 32(7):663-670.

Description:

Duchenne and Becker muscular dystrophy are X-linked neuromuscular disorders characterized by progressive muscle degeneration. Despite the involvement of multiple systems, secondary conditions among affected males have not been comprehensively describ...

File Type:

[PDF - 632.91 KB]
Hospitalizations and Emergency Room Visits for Adolescents and Young Adults with Muscular Dystrophy Living in South Carolina

Personal Author:

Mann, Joshua R.; Royer, Julie A.; McDermott, Suzanne; Hardin, James W.; Ozturk, Orgul; Street, Natalie;

Published:

Aug 14 2015

Source:

Muscle Nerve. 52(5):714-721.

Description:

Introduction : Transitioning from adolescence to adulthood can be problematic for individuals with rare disabilities such as muscular dystrophy (MD). : Methods : We identified a cohort of 220 individuals with MD and 440 matched comparison individuals...

File Type:

[PDF - 218.75 KB]
Age at onset of first signs or symptoms predicts age at loss of ambulation in Duchenne and Becker Muscular Dystrophy: Data from the MD STARnet

Personal Author:

Ciafaloni, Emma; Kumar, Anil; Liu, Ke; Pandya, Shree; Westfield, Christina; Fox, Deborah J.; Caspers Conway, Kristin M.; Cunniff, Christopher; Mathews, Katherine; West, Nancy; Romitti, Paul A.; McDermott, Michael P.;

Published:

2016

Source:

J Pediatr Rehabil Med. 9(1):5-11.

Description:

PURPOSE : We investigated the prognostic utility of onset age at first signs and symptoms (SS) to predict onset age at loss of ambulation (LOA) for childhood-onset Duchenne and Becker Muscular Dystrophies (DBMD). : METHODS : Our cohort comprised male...

File Type:

[PDF - 263.69 KB]
Complementary and Alternative Medicine for Duchenne and Becker Muscular Dystrophies: Characteristics of Users and Caregivers

Personal Author:

Zhu, Yong; Romitti, Paul A.; Conway, Kristin M.; Andrews, Jennifer; Liu, Ke; Meaney, F. John; Street, Natalie; Puzhankara, Soman; Druschel, Charlotte M.; Matthews, Dennis J.;

Published:

Feb 15 2014

Source:

Pediatr Neurol. 2014; 51(1):71-77.

Description:

BACKGROUND : Complementary and alternative medicine is frequently used in the management of chronic pediatric diseases, but little is known about its use by those with Duchenne or Becker muscular dystrophy. : METHODS : Complementary and alternative m...

File Type:

[PDF - 274.09 KB]
Bone Health and Endocrine Care of Boys with Duchenne Muscular Dystrophy: Data from the MD STARnet

Personal Author:

Weber, David R.; Thomas, Shiny; Erickson, Stephen W.; Fox, Deborah; Oleszek, Joyce; Pandya, Shree; Venkatesh, Yedatore; Westfield, Christina; Ciafaloni, Emma;

Corporate Author:

Muscular Dystrophy Tracking and Research Network (MD STARnet)

Published:

2018

Source:

J Neuromuscul Dis. 5(4):497-507

Description:

Background: : Patients with Duchenne muscular dystrophy (DMD) are at high risk of endocrine and bone health complications resulting from the high glucocorticoid (GC) doses used to treat this condition. There are limited data characterizing the clinic...

File Type:

[PDF - 1.20 MB]