Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies

Zhu, Yong; Romitti, Paul A.; Conway, Kristin M. Caspers; Kim, Sunkyung; Zhang, Ying; Yang, Michele; Mathews, Katherine D.

doi:10.1002/mus.24486

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies

Published Date:

Jun 03 2015

Publisher's site:

http://dx.doi.org/10.1002/mus.24486 New Site Icon

Source:

Muscle Nerve. 52(1):22-27.

[PDF-227.87 KB]

Details:

Personal Authors:

Zhu, Yong ; Romitti, Paul A. ; Conway, Kristin M. Caspers ; Kim, Sunkyung ; Zhang, Ying ; ... More ▼

Corporate Authors:

MD STARnet

Keywords:

[+]

Pubmed ID:

25297835

Pubmed Central ID:

PMC4412791

Description:

Introduction

Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data.

Methods

Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, hazard ratios (HR) and 95% confidence intervals (CI) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early-versus late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids).

Results

Among the 918 males, 81 (9%) had a GU condition; voiding dysfunction (n=40), GU tract infection (n=19), and kidney/ureter calculus (n=9) were most common. A Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR=2.7, 95% CI=1.3-5.6).

Discussion

These findings highlight increased awareness of GU health and multidisciplinary care of DBMD patients.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States
U01 DD000831/DD/NCBDD CDC HHS/United States
U01 DD001119/DD/NCBDD CDC HHS/United States
UL1 TR001108/TR/NCATS NIH HHS/United States

Supporting Files:

	nihms-682902-f0001.gif	image/gif
	nihms-682902-f0001.jpg	image/jpeg
	nihms-682902.nxml	application/octet-stream

No Related Documents.

You May Also Like:

Secondary conditions among males with Duchenne or Becker muscular dystrophy

Personal Author:

Latimer, Rebecca; Street, Natalie; Conway, Kristin Caspers; James, Kathy; Cunniff, Christopher; Oleszek, Joyce; Fox, Deborah; Ciafaloni, Emma; Westfield, Christina; Paramsothy, Pangaja;

Corporate Author:

Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STAR

Published:

Apr 09 2017

Source:

J Child Neurol. 32(7):663-670.

Description:

Duchenne and Becker muscular dystrophy are X-linked neuromuscular disorders characterized by progressive muscle degeneration. Despite the involvement of multiple systems, secondary conditions among affected males have not been comprehensively describ...

File Type:

[PDF - 632.91 KB]
Hospitalizations and Emergency Room Visits for Adolescents and Young Adults with Muscular Dystrophy Living in South Carolina

Personal Author:

Mann, Joshua R.; Royer, Julie A.; McDermott, Suzanne; Hardin, James W.; Ozturk, Orgul; Street, Natalie;

Published:

Aug 14 2015

Source:

Muscle Nerve. 52(5):714-721.

Description:

Introduction : Transitioning from adolescence to adulthood can be problematic for individuals with rare disabilities such as muscular dystrophy (MD). : Methods : We identified a cohort of 220 individuals with MD and 440 matched comparison individuals...

File Type:

[PDF - 218.75 KB]
Age at onset of first signs or symptoms predicts age at loss of ambulation in Duchenne and Becker Muscular Dystrophy: Data from the MD STARnet

Personal Author:

Ciafaloni, Emma; Kumar, Anil; Liu, Ke; Pandya, Shree; Westfield, Christina; Fox, Deborah J.; Caspers Conway, Kristin M.; Cunniff, Christopher; Mathews, Katherine; West, Nancy; Romitti, Paul A.; McDermott, Michael P.;

Published:

2016

Source:

J Pediatr Rehabil Med. 9(1):5-11.

Description:

PURPOSE : We investigated the prognostic utility of onset age at first signs and symptoms (SS) to predict onset age at loss of ambulation (LOA) for childhood-onset Duchenne and Becker Muscular Dystrophies (DBMD). : METHODS : Our cohort comprised male...

File Type:

[PDF - 263.69 KB]
Complementary and Alternative Medicine for Duchenne and Becker Muscular Dystrophies: Characteristics of Users and Caregivers

Personal Author:

Zhu, Yong; Romitti, Paul A.; Conway, Kristin M.; Andrews, Jennifer; Liu, Ke; Meaney, F. John; Street, Natalie; Puzhankara, Soman; Druschel, Charlotte M.; Matthews, Dennis J.;

Published:

Feb 15 2014

Source:

Pediatr Neurol. 2014; 51(1):71-77.

Description:

BACKGROUND : Complementary and alternative medicine is frequently used in the management of chronic pediatric diseases, but little is known about its use by those with Duchenne or Becker muscular dystrophy. : METHODS : Complementary and alternative m...

File Type:

[PDF - 274.09 KB]
Application of the International Classification of Functioning, Disability and Health System to symptoms of Duchenne and Becker muscular dystrophies

Personal Author:

Conway, Kristin M; Ciafaloni, Emma; Matthews, Dennis; Westfield, Chris; James, Kathy; Paramsothy, Pangaja; Romitti, Paul A;

Published:

Apr 11 2017

Source:

Disabil Rehabil. 40(15):1773-1780.

Description:

Purpose : Duchenne and Becker muscular dystrophies, collectively referred to as dystrophinopathies, are X-linked recessive diseases that affect dystrophin production resulting in compromised muscle function across multiple systems. The International ...

Public Access
Available on:

July 01, 2019