Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies
Published Date:Jun 03 2015
Source:Muscle Nerve. 52(1):22-27.
Corporate Authors:MD STARnet
Becker Muscular Dystrophy
Duchenne Muscular Dystrophy
Male Urogenital Diseases
Muscular Dystrophy, Duchenne
Pubmed Central ID:PMC4412791
Funding:CC999999/Intramural CDC HHS/United States
U01 DD000831/DD/NCBDD CDC HHS/United States
U01 DD001119/DD/NCBDD CDC HHS/United States
UL1 TR001108/TR/NCATS NIH HHS/United States
Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data.
Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, hazard ratios (HR) and 95% confidence intervals (CI) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early-versus late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids).
Among the 918 males, 81 (9%) had a GU condition; voiding dysfunction (n=40), GU tract infection (n=19), and kidney/ureter calculus (n=9) were most common. A Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR=2.7, 95% CI=1.3-5.6).
These findings highlight increased awareness of GU health and multidisciplinary care of DBMD patients.
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