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Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies
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Jun 03 2015
Source: Muscle Nerve. 52(1):22-27.
[PDF-227.87 KB]
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Alternative Title:Muscle Nerve
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Description:Introduction
Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data.
Methods
Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, hazard ratios (HR) and 95% confidence intervals (CI) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early-versus late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids).
Results
Among the 918 males, 81 (9%) had a GU condition; voiding dysfunction (n=40), GU tract infection (n=19), and kidney/ureter calculus (n=9) were most common. A Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR=2.7, 95% CI=1.3-5.6).
Discussion
These findings highlight increased awareness of GU health and multidisciplinary care of DBMD patients.
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Pubmed ID:25297835
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Pubmed Central ID:PMC4412791
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