Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies

Zhu, Yong; Romitti, Paul A.; Conway, Kristin M. Caspers; Kim, Sunkyung; Zhang, Ying; Yang, Michele; Mathews, Katherine D.

doi:10.1002/mus.24486

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Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies

Published Date:

Jun 03 2015

Publisher's site:

http://dx.doi.org/10.1002/mus.24486 New Site Icon

Source:

Muscle Nerve. 52(1):22-27.

[PDF - 227.87 KB]

Details:

Personal Authors:

Zhu, Yong ; Romitti, Paul A. ; Conway, Kristin M. Caspers ; Kim, Sunkyung ; Zhang, Ying ; ... More ▼

Corporate Authors:

MD STARnet

Keywords:

[+]

Pubmed ID:

25297835

Pubmed Central ID:

PMC4412791

Description:

Introduction

Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data.

Methods

Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, hazard ratios (HR) and 95% confidence intervals (CI) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early-versus late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids).

Results

Among the 918 males, 81 (9%) had a GU condition; voiding dysfunction (n=40), GU tract infection (n=19), and kidney/ureter calculus (n=9) were most common. A Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR=2.7, 95% CI=1.3-5.6).

Discussion

These findings highlight increased awareness of GU health and multidisciplinary care of DBMD patients.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States
U01 DD000831/DD/NCBDD CDC HHS/United States
U01 DD001119/DD/NCBDD CDC HHS/United States
UL1 TR001108/TR/NCATS NIH HHS/United States

Supporting Files:

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nihms-682902-f0001.jpg	image/jpeg
nihms-682902.nxml	application/octet-stream

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