Details:

Alternative Title:
Muscle Nerve
Personal Author:
Zhu, Yong ; Romitti, Paul A. ; Conway, Kristin M. Caspers ; Kim, Sunkyung ; Zhang, Ying ; ... More +
Zhu, Yong ; Romitti, Paul A. ; Conway, Kristin M. Caspers ; Kim, Sunkyung ; Zhang, Ying ; Yang, Michele ; Mathews, Katherine D. ; Less -
Corporate Authors:
MD STARnet ;
Description:
Introduction Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data. Methods Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, hazard ratios (HR) and 95% confidence intervals (CI) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early-versus late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids). Results Among the 918 males, 81 (9%) had a GU condition; voiding dysfunction (n=40), GU tract infection (n=19), and kidney/ureter calculus (n=9) were most common. A Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR=2.7, 95% CI=1.3-5.6). Discussion These findings highlight increased awareness of GU health and multidisciplinary care of DBMD patients.
Subject:
[+]
Adolescent
Adult
Article
Becker Muscular Dystrophy
Child
Child, Preschool
Cohort Studies
Duchenne Muscular Dystrophy
Epidemiology
Hospitalization
Humans
Incidence
Kaplan-Meier Estimate
Male
Male Urogenital Diseases
Muscular Dystrophy, Duchenne
Neuromuscular Diseases
Population Surveillance
Risk
Young Adult
Male Urogenital Diseases

Source:
Muscle Nerve. 52(1):22-27. ;
Pubmed ID:
25297835
Pubmed Central ID:
PMC4412791
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ; U01 DD000831/DD/NCBDD CDC HHS/United States ; U01 DD001119/DD/NCBDD CDC HHS/United States ; UL1 TR001108/TR/NCATS NIH HHS/United States ;
CC999999/Intramural CDC HHS/United States ; U01 DD000831/DD/NCBDD CDC HHS/United States ; U01 DD001119/DD/NCBDD CDC HHS/United States ; UL1 TR001108/TR/NCATS NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:767b7259c16167c4e138341cc464e788ac10cdad1dfa59bc543aac1e9a7e2bc4
File Type:

Supporting Files

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