Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies

Details

• Alternative Title:
  Muscle Nerve
• Personal Author:
  Zhu, Yong ; Romitti, Paul A. ; Conway, Kristin M. Caspers ; Kim, Sunkyung ; Zhang, Ying ; Yang, Michele ; Mathews, Katherine D.
• Corporate Authors:
  MD STARnet
• Description:
  Introduction
  
  Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data.
  
  Methods
  
  Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, hazard ratios (HR) and 95% confidence intervals (CI) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early-versus late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids).
  
  Results
  
  Among the 918 males, 81 (9%) had a GU condition; voiding dysfunction (n=40), GU tract infection (n=19), and kidney/ureter calculus (n=9) were most common. A Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR=2.7, 95% CI=1.3-5.6).
  
  Discussion
  
  These findings highlight increased awareness of GU health and multidisciplinary care of DBMD patients.
  
  
• Subjects:
  Adolescent Adult Article Becker Muscular Dystrophy Child Child, Preschool Cohort Studies Duchenne Muscular Dystrophy Epidemiology Hospitalization Humans Incidence Kaplan-Meier Estimate Male Male Urogenital Diseases Muscular Dystrophy, Duchenne Neuromuscular Diseases Population Surveillance Risk Young Adult

  More +
• Source:
  Muscle Nerve. 52(1):22-27.
• Pubmed ID:
  25297835
• Pubmed Central ID:
  PMC4412791
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; U01 DD000831/DD/NCBDD CDC HHS/United States ; U01 DD001119/DD/NCBDD CDC HHS/United States ; UL1 TR001108/TR/NCATS NIH HHS/United States
• Volume:
  52
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:767b7259c16167c4e138341cc464e788ac10cdad1dfa59bc543aac1e9a7e2bc4
• Download URL:
  https://stacks.cdc.gov/view/cdc/30748/cdc_30748_DS1.pdf
• File Type:
  [PDF - 227.87 KB ]