Details:

Alternative Title:
Muscle Nerve
Personal Author:
PETTYGROVE, SYDNEY ; LU, ZHENQIANG ; ANDREWS, JENNIFER G. ; MEANEY, F. JOHN ; SHEEHAN, DANIEL W. ; ... More +
PETTYGROVE, SYDNEY ; LU, ZHENQIANG ; ANDREWS, JENNIFER G. ; MEANEY, F. JOHN ; SHEEHAN, DANIEL W. ; PRICE, ELINORA T. ; FOX, DEBORAH J. ; PANDYA, SHREE ; OUYANG, LIJING ; APKON, SUSAN D. ; POWIS, ZOE ; CUNNIFF, CHRISTOPHER Less -
Description:
Introduction

The correlation of markers of disease severity among brothers with Duchenne or Becker muscular dystrophy has implications for clinical guidance and clinical trials.

Methods

Sibling pairs with Duchenne or Becker muscular dystrophy (n = 60) were compared for ages when they reached clinical milestones of disease progression, including ceased ambulation, scoliosis of ≥ 20°, and development of cardiomyopathy.

Results

The median age at which younger brothers reached each milestone, compared with their older brothers ranged from 25 months younger for development of cardiomyopathy to 2 months older for ceased ambulation. For each additional month of ambulation by the older brother, the hazard of ceased ambulation by the younger brother decreased by 4%.

Conclusions

The ages when siblings reach clinical milestones of disease vary widely between siblings. However, the time to ceased ambulation for older brothers predicts the time to ceased ambulation for their younger brothers.


Subjects:
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Age Factors Ambulation Article Becker Muscular Dystrophy Cardiomyopathies Cardiomyopathy Child Child, Preschool Disease Progression Duchenne Muscular Dystrophy Humans Incidence Male Muscular Dystrophy, Duchenne Prognosis Retrospective Studies Scoliosis Sibling Features Siblings
Source:
Muscle Nerve. 2013; 49(6):814-821.
Pubmed ID:
24030636
Pubmed Central ID:
PMC4481732
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; U01 DD000187/DD/NCBDD CDC HHS/United States ; DD000187/DD/NCBDD CDC HHS/United States
CC999999/Intramural CDC HHS/United States ; U01 DD000187/DD/NCBDD CDC HHS/United States ; DD000187/DD/NCBDD CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1d56553fc1cb107e228e44c192c74ebf5a875093d5c98d42ad10282d02e051dc
Download URL:
https://stacks.cdc.gov/view/cdc/31762/cdc_31762_DS1.pdf
File Type:

Supporting Files

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