i
SIBLING CONCORDANCE FOR CLINICAL FEATURES OF DUCHENNE AND BECKER MUSCULAR DYSTROPHIES
-
Jun 2014
Source: Muscle Nerve. 2013; 49(6):814-821.
[PDF-395.73 KB]
Details:
-
Alternative Title:Muscle Nerve
-
Personal Author:
-
Description:Introduction
The correlation of markers of disease severity among brothers with Duchenne or Becker muscular dystrophy has implications for clinical guidance and clinical trials.
Methods
Sibling pairs with Duchenne or Becker muscular dystrophy (n = 60) were compared for ages when they reached clinical milestones of disease progression, including ceased ambulation, scoliosis of ≥ 20°, and development of cardiomyopathy.
Results
The median age at which younger brothers reached each milestone, compared with their older brothers ranged from 25 months younger for development of cardiomyopathy to 2 months older for ceased ambulation. For each additional month of ambulation by the older brother, the hazard of ceased ambulation by the younger brother decreased by 4%.
Conclusions
The ages when siblings reach clinical milestones of disease vary widely between siblings. However, the time to ceased ambulation for older brothers predicts the time to ceased ambulation for their younger brothers.
-
Subject:
-
Pubmed ID:24030636
-
Pubmed Central ID:PMC4481732
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
-
File Type:
Supporting Files
-
xml 
gif 
jpeg 
gif 
jpeg
More +
Email
CDC-INFO
