SIBLING CONCORDANCE FOR CLINICAL FEATURES OF DUCHENNE AND BECKER MUSCULAR DYSTROPHIES

PETTYGROVE, SYDNEY; LU, ZHENQIANG; ANDREWS, JENNIFER G.; MEANEY, F. JOHN; SHEEHAN, DANIEL W.; PRICE, ELINORA T.; FOX, DEBORAH J.; PANDYA, SHREE; OUYANG, LIJING; APKON, SUSAN D.; POWIS, ZOE; CUNNIFF, CHRISTOPHER

doi:10.1002/mus.24078

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

SIBLING CONCORDANCE FOR CLINICAL FEATURES OF DUCHENNE AND BECKER MUSCULAR DYSTROPHIES

Published Date:

Jun 2014

Publisher's site:

http://dx.doi.org/10.1002/mus.24078 New Site Icon

Source:

Muscle Nerve. 2013; 49(6):814-821.

[PDF - 395.73 KB]

Details:

Personal Authors:

PETTYGROVE, SYDNEY ; LU, ZHENQIANG ; ANDREWS, JENNIFER G. ; MEANEY, F. JOHN ; SHEEHAN, DANIEL W. ; ... More ▼

Keywords:

[+]

Pubmed ID:

24030636

Pubmed Central ID:

PMC4481732

Description:

Introduction

The correlation of markers of disease severity among brothers with Duchenne or Becker muscular dystrophy has implications for clinical guidance and clinical trials.

Methods

Sibling pairs with Duchenne or Becker muscular dystrophy (n = 60) were compared for ages when they reached clinical milestones of disease progression, including ceased ambulation, scoliosis of ≥ 20°, and development of cardiomyopathy.

Results

The median age at which younger brothers reached each milestone, compared with their older brothers ranged from 25 months younger for development of cardiomyopathy to 2 months older for ceased ambulation. For each additional month of ambulation by the older brother, the hazard of ceased ambulation by the younger brother decreased by 4%.

Conclusions

The ages when siblings reach clinical milestones of disease vary widely between siblings. However, the time to ceased ambulation for older brothers predicts the time to ceased ambulation for their younger brothers.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States
DD000187/DD/NCBDD CDC HHS/United States

Supporting Files:

nihms701609.nxml	application/octet-stream
nihms701609f1.gif	image/gif
nihms701609f1.jpg	image/jpeg
nihms701609f2.gif	image/gif
nihms701609f2.jpg	image/jpeg

No Related Documents.

You May Also Like:

Complementary and Alternative Medicine for Duchenne and Becker Muscular Dystrophies: Characteristics of Users and Caregivers

Personal Author:

Zhu, Yong; Romitti, Paul A.; Conway, Kristin M.; Andrews, Jennifer; Liu, Ke; Meaney, F. John; Street, Natalie; Puzhankara, Soman; Druschel, Charlotte M.; Matthews, Dennis J.;

Published:

Feb 15 2014

Source:

Pediatr Neurol. 2014; 51(1):71-77.

Description:

BACKGROUND : Complementary and alternative medicine is frequently used in the management of chronic pediatric diseases, but little is known about its use by those with Duchenne or Becker muscular dystrophy. : METHODS : Complementary and alternative m...

File Type:

[PDF - 274.09 KB]
Prevalence of Duchenne and Becker Muscular Dystrophies in the United States

Personal Author:

Romitti, Paul A.; Zhu, Yong; Puzhankara, Soman; James, Katherine A.; Nabukera, Sarah K.; Zamba, Gideon K.D.; Ciafaloni, Emma; Cunniff, Christopher; Druschel, Charlotte M.; Mathews, Katherine D.; Matthews, Dennis J.; Meaney, F. John; Andrews, Jennifer G.; Caspers Conway, Kristin M.; Fox, Deborah J.; Street, Natalie; Adams, Melissa M.; Bolen, Julie;

Published:

Feb 16 2015

Source:

Pediatrics. 2015; 135(3):513-521.

Description:

OBJECTIVE : To estimate prevalence of childhood-onset Duchenne and Becker muscular dystrophies (DBMD) in 6 sites in the United States by race/ethnicity and phenotype (Duchenne muscular dystrophy [DMD] or Becker muscular dystrophy [BMD]). : METHODS : ...

File Type:

[PDF - 631.51 KB]
Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies

Personal Author:

Zhu, Yong; Romitti, Paul A.; Conway, Kristin M. Caspers; Kim, Sunkyung; Zhang, Ying; Yang, Michele; Mathews, Katherine D.;

Corporate Author:

MD STARnet

Published:

Jun 03 2015

Source:

Muscle Nerve. 52(1):22-27.

Description:

Introduction : Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data. : Methods : Medical records of 918 males ascertained by the Muscular Dystrophy Surveillanc...

File Type:

[PDF - 227.87 KB]