Health Profile of Preterm Males With Duchenne Muscular Dystrophy

Details

• Alternative Title:
  J Child Neurol
• Personal Author:
  Soim, Aida ; Wallace, Bailey ; Whitehead, Nedra ; Smith, Michael G. ; Mann, Joshua R. ; Thomas, Shiny ; Ciafaloni, Emma
• Corporate Authors:
  Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet)
• Description:
  In this retrospective cohort study, we characterize the health profile of preterm males with Duchenne muscular dystrophy. Major clinical milestones (ambulation cessation, assisted ventilation use, and onset of left ventricular dysfunction) and corticosteroids use in males with Duchenne muscular dystrophy identified through a population-based surveillance system were analyzed using Kaplan-Meier survival curves and Cox proportional hazards modeling. The adjusted risk of receiving any respiratory intervention among preterm males with Duchenne muscular dystrophy was 87% higher than among the corresponding full-term males with Duchenne muscular dystrophy. The adjusted risks for ambulation cessation and left ventricular dysfunction were modestly elevated among preterm compared to full-term males, but the 95% confidence intervals contained the null. No difference in the start of corticosteroid use between preterm and full-term Duchenne muscular dystrophy males was observed. Overall, the disease course seems to be similar between preterm and full-term males with Duchenne muscular dystrophy; however, pulmonary function seems to be affected earlier among preterm males with Duchenne muscular dystrophy.
• Subjects:
  Adolescent Causality Child Child, Preschool Cohort Studies Comorbidity Disease Progression Gait Disorders, Neurologic Health Status Humans Infant, Newborn Infant, Premature Kaplan-Meier Estimate Male Muscular Dystrophy, Duchenne Population Surveillance Respiration, Artificial Retrospective Studies United States Ventricular Dysfunction, Left

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• Keywords:
  Children Epidemiology Duchenne Muscular Dystrophy Pediatric Preterm
• Source:
  J Child Neurol. 36(12):1095-1102
• Pubmed ID:
  34677095
• Pubmed Central ID:
  PMC10928516
• Document Type:
  Journal Article
• Funding:
  U01 DD001117/DD/NCBDD CDC HHSUnited States/ ; U01 DD000187/DD/NCBDD CDC HHSUnited States/ ; U01 DD000189/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD000191/DD/NCBDD CDC HHSUnited States/ ; U01 DD001250/DD/NCBDD CDC HHSUnited States/ ; U01DD001117/ACL/ACL HHSUnited States/ ; U01 DD001255/DD/NCBDD CDC HHSUnited States/ ; U01 DD000190/DD/NCBDD CDC HHSUnited States/
• Volume:
  36
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8db31ba7915274d6be0564a2208497a8a425730ca3592b53954141b3a9a5e5c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/151673/cdc_151673_DS1.pdf
• File Type:
  [PDF - 1.27 MB ]