The Association of Bisphenol-A Urinary Concentrations with Antral Follicle Counts and Other Measures of Ovarian Reserve in Women Undergoing Infertility Treatments.☆

Details

• Alternative Title:
  Reprod Toxicol
• Personal Author:
  Souter, Irene ; Smith, Kristen W ; Dimitriadis, Irene ; Ehrlich, Shelley ; Williams, Paige L ; Calafat, Antonia M ; Hauser, Russ
• Description:
  In this prospective cohort of women undergoing infertility treatments, we measured specific-gravity adjusted urinary BPA (SG-BPA) concentrations and used regression models to evaluate the association of BPA with antral follicle count (AFC), day-3 serum follicle stimulating hormone levels (FSH), and ovarian volume (OV). BPA, detected in >80% of women, had a geometric mean (±GSD) of 1.6±2.0, 1.7±2.1, and 1.5±1.8μg/L for the women contributing to the AFC (n=154), day-3 FSH (n=120), and OV (n=114) analyses, respectively. There was an average decrease in AFC of 12% (95% CI: -23%, -0.6%), 22% (95% CI: -31%, -11%), and 17% (95% CI: -27%, -6%), in the 2nd, 3rd, and 4th SG-BPA quartile compared to the 1st quartile, respectively (p-trend: <0.001). No association of SG-BPA with FSH or OV was observed. Among women from an infertility clinic, higher urinary BPA concentrations were associated with lower AFC, raising concern for possible accelerated follicle loss and reproductive aging.
• Subjects:
  Adult Antral Follicle Count Article Benzhydryl Compounds Bisphenol-A Day-3 Follicle Stimulating Hormone Endocrine Disruptors Female Follicle Stimulating Hormone Humans Infertility, Female Middle Aged Organ Size Ovarian Follicle Ovarian Reserve Ovarian Volume Ovary Phenols Young Adult

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• Source:
  Reprod Toxicol. 2013; 42:224-231.
• Pubmed ID:
  24100206
• Pubmed Central ID:
  PMC4383527
• Document Type:
  Journal Article
• Funding:
  ES000002/ES/NIEHS NIH HHS/United States ; ES009718/ES/NIEHS NIH HHS/United States ; OH008578/OH/NIOSH CDC HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 ES009718/ES/NIEHS NIH HHS/United States ; R01 OH008578/OH/NIOSH CDC HHS/United States ; T32ES007069/ES/NIEHS NIH HHS/United States
• Volume:
  42
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ddb1b520b80b2f000f475a3a723162b8192ba4c3e4b6c668639b73f46c713108
• Download URL:
  https://stacks.cdc.gov/view/cdc/30358/cdc_30358_DS1.pdf
• File Type:
  [PDF - 519.49 KB ]