Details:

Alternative Title:
Reprod Toxicol
Publisher's site:
http://dx.doi.org/10.1016/j.reprotox.2013.09.008
Personal Author:
Souter, Irene ; Smith, Kristen W ; Dimitriadis, Irene ; Ehrlich, Shelley ; Williams, Paige L ; ... More +
Souter, Irene ; Smith, Kristen W ; Dimitriadis, Irene ; Ehrlich, Shelley ; Williams, Paige L ; Calafat, Antonia M ; Hauser, Russ Less -
Description:
In this prospective cohort of women undergoing infertility treatments, we measured specific-gravity adjusted urinary BPA (SG-BPA) concentrations and used regression models to evaluate the association of BPA with antral follicle count (AFC), day-3 serum follicle stimulating hormone levels (FSH), and ovarian volume (OV). BPA, detected in >80% of women, had a geometric mean (±GSD) of 1.6±2.0, 1.7±2.1, and 1.5±1.8μg/L for the women contributing to the AFC (n=154), day-3 FSH (n=120), and OV (n=114) analyses, respectively. There was an average decrease in AFC of 12% (95% CI: -23%, -0.6%), 22% (95% CI: -31%, -11%), and 17% (95% CI: -27%, -6%), in the 2nd, 3rd, and 4th SG-BPA quartile compared to the 1st quartile, respectively (p-trend: <0.001). No association of SG-BPA with FSH or OV was observed. Among women from an infertility clinic, higher urinary BPA concentrations were associated with lower AFC, raising concern for possible accelerated follicle loss and reproductive aging.
Subject:
[+]
Adult
Antral Follicle Count
Article
Benzhydryl Compounds
Bisphenol-A
Day-3 Follicle Stimulating Hormone
Endocrine Disruptors
Female
Follicle Stimulating Hormone
Humans
Infertility, Female
Middle Aged
Organ Size
Ovarian Follicle
Ovarian Reserve
Ovarian Volume
Ovary
Phenols
Young Adult

Source:
Reprod Toxicol. 2013; 42:224-231.
Pubmed ID:
24100206
Pubmed Central ID:
PMC4383527
Document Type:
Journal Article
Funding:
ES000002/ES/NIEHS NIH HHS/United States ; ES009718/ES/NIEHS NIH HHS/United States ; OH008578/OH/NIOSH CDC HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 ES009718/ES/NIEHS NIH HHS/United States ; ... More +
ES000002/ES/NIEHS NIH HHS/United States ; ES009718/ES/NIEHS NIH HHS/United States ; OH008578/OH/NIOSH CDC HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 ES009718/ES/NIEHS NIH HHS/United States ; R01 OH008578/OH/NIOSH CDC HHS/United States ; T32ES007069/ES/NIEHS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ddb1b520b80b2f000f475a3a723162b8192ba4c3e4b6c668639b73f46c713108
File Type:

Supporting Files

• 	NIHMS671465-supplement-1.docx	docx
  	NIHMS671465-supplement-2.docx	docx
  	NIHMS671465-supplement-3.docx	docx
  	NIHMS671465-supplement-4.docx	docx
  	nihms671465.nxml	bin

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