The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments

Details

• Personal Author:
  Calafat, Antonia M. ; Dimitriadis I ; Ehrlich S ; Hauser R ; Smith KW ; Souter I ; Williams PL
• Description:
  In this prospective cohort of women undergoing infertility treatments, we measured specific-gravity adjusted urinary BPA (SG-BPA) concentrations and used regression models to evaluate the association of BPA with antral follicle count (AFC), day-3 serum follicle stimulating hormone levels (FSH), and ovarian volume (OV). BPA, detected in >80% of women, had a geometric mean (+/-GSD) of 1.6+/-2.0, 1.7+/-2.1, and 1.5+/-1.8 µg/L for the women contributing to the AFC (n=154), day-3 FSH (n=120), and OV (n=114) analyses, respectively. There was an average decrease in AFC of 12% (95% CI: -23%, -0.6%), 22% (95% CI: -31%, -11%), and 17% (95% CI: -27%, -6%), in the 2nd, 3rd, and 4th SG-BPA quartile compared to the 1st quartile, respectively (p-trend: <0.001). No association of SG-BPA with FSH or OV was observed. Among women from an infertility clinic, higher urinary BPA concentrations were associated with lower AFC, raising concern for possible accelerated follicle loss and reproductive aging. [Description provided by NIOSH]
• Subjects:
  Endocrine System Estrogens Hazardous Substances Occupational Health Phenol Safety Steroids Toxicology Urine Urogenital System Women

  More +
• Keywords:
  Antral Follicle Count Author Keywords: Bisphenol-A Day-3 Follicle Stimulating Hormone Endocrine-function Estrogenic-hormones Fertility Hormone-activity Hormones Humans Mathematical-models Medical-treatment Ovarian Reserve Ovarian Volume Phenols Reproductive-effects Reproductive-system Statistical-analysis Toxic-materials Urinalysis

  More +
• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  224-231
• Volume:
  42
• NIOSHTIC Number:
  nn:20044683
• Citation:
  Reprod Toxicol 2013 Dec; 42:224-231
• Contact Point Address:
  Irene Souter, Massachusetts General Hospital Fertility Center,Yawkey 10-A, 55 Fruit Street, Boston, MA 02114, USA
• Email:
  isouter@partners.org
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2014
• Performing Organization:
  Harvard University, School of Public Health, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20090630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3d6508cd91220eb5ce204dff9714b856b6402d344633383cf1b57603d01bff6d79bb7ea33865e7e06057a0ff995ea60e545d789273fcdda9b55e244ca7d19eba
• Download URL:
  https://stacks.cdc.gov/view/cdc/200328/cdc_200328_DS1.pdf
• File Type:
  [PDF - 780.34 KB ]