A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Details

• Alternative Title:
  Nat Commun
• Personal Author:
  Vijai, Joseph ; Wang, Zhaoming ; Berndt, Sonja I ; Skibola, Christine F ; Slager, Susan L ; de Sanjose, Silvia ; Melbye, Mads ; Glimelius, Bengt ; Bracci, Paige M ; Conde, Lucia ; Birmann, Brenda M ; Wang, Sophia S ; Brooks-Wilson, Angela R ; Lan, Qing ; de Bakker, Paul I W ; Vermeulen, Roel C H ; Portlock, Carol ; Ansell, Stephen M ; Link, Brian K ; Riby, Jacques ; North, Kari E ; Gu, Jian ; Hjalgrim, Henrik ; Cozen, Wendy ; Becker, Nikolaus ; Teras, Lauren R ; Spinelli, John J ; Turner, Jenny ; Zhang, Yawei ; Purdue, Mark P ; Giles, Graham G ; Kelly, Rachel S ; Zeleniuch-Jacquotte, Anne ; Ennas, Maria Grazia ; Monnereau, Alain ; Bertrand, Kimberly A ; Albanes, Demetrius ; Lightfoot, Tracy ; Yeager, Meredith ; Chung, Charles C ; Burdett, Laurie ; Hutchinson, Amy ; Lawrence, Charles ; Montalvan, Rebecca ; Liang, Liming ; Huang, Jinyan ; Ma, Baoshan ; Villano, Danylo J ; Maria, Ann ; Corines, Marina ; Thomas, Tinu ; Novak, Anne J ; Dogan, Ahmet ; Liebow, Mark ; Thompson, Carrie A ; Witzig, Thomas E ; Habermann, Thomas M ; Weiner, George J ; Smith, Martyn T ; Holly, Elizabeth A ; Jackson, Rebecca D ; Tinker, Lesley F ; Ye, Yuanqing ; Adami, Hans-Olov ; Smedby, Karin E ; De Roos, Anneclaire J ; Hartge, Patricia ; Morton, Lindsay M ; Severson, Richard K ; Benavente, Yolanda ; Boffetta, Paolo ; Brennan, Paul ; Foretova, Lenka ; Maynadie, Marc ; McKay, James ; Staines, Anthony ; Diver, W Ryan ; Vajdic, Claire M ; Armstrong, Bruce K ; Kricker, Anne ; Zheng, Tongzhang ; Holford, Theodore R ; Severi, Gianluca ; Vineis, Paolo ; Ferri, Giovanni M ; Ricco, Rosalia ; Miligi, Lucia ; Clavel, Jacqueline ; Giovannucci, Edward ; Kraft, Peter ; Virtamo, Jarmo ; Smith, Alex ; Kane, Eleanor ; Roman, Eve ; Chiu, Brian C H ; Fraumeni, Joseph F ; Wu, Xifeng ; Cerhan, James R ; Offit, Kenneth ; Chanock, Stephen J ; Rothman, Nathaniel ; Nieters, Alexandra
• Description:
  Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
• Subjects:
  Butyrophilins Computational Biology Genome-Wide Association Study Genotype Humans Lymphoma, B-Cell, Marginal Zone Major Histocompatibility Complex Membrane Glycoproteins Polymorphism, Single Nucleotide White People
• Source:
  Nat Commun. 6:5751
• Pubmed ID:
  25569183
• Pubmed Central ID:
  PMC4287989
• Document Type:
  Journal Article
• Funding:
  P01 CA087969/CA/NCI NIH HHS/United States ; HHSN268201100004I/HL/NHLBI NIH HHS/United States ; CA098122/CA/NCI NIH HHS/United States ; UM1 CA167552/CA/NCI NIH HHS/United States ; N01RC37004/RC/CCR NIH HHS/United States ; UL1 TR000430/TR/NCATS NIH HHS/United States ; CA167552/CA/NCI NIH HHS/United States ; N01 PC067009/CN/NCI NIH HHS/United States ; N02-PC-71105/PC/NCI NIH HHS/United States ; HHSN268201100001I/HL/NHLBI NIH HHS/United States ; N01-RC-45035/RC/CCR NIH HHS/United States ; P30 CA016672/CA/NCI NIH HHS/United States ; P30 CA016087/CA/NCI NIH HHS/United States ; HHSN261201000140C/CA/NCI NIH HHS/United States ; CA97274/CA/NCI NIH HHS/United States ; N01 PC067010/PC/NCI NIH HHS/United States ; R01 CA098122/CA/NCI NIH HHS/United States ; U01 HG007033/HG/NHGRI NIH HHS/United States ; K07 CA115687/CA/NCI NIH HHS/United States ; CA098566/CA/NCI NIH HHS/United States ; R21 CA178800/CA/NCI NIH HHS/United States ; HHSN268201100046C/HL/NHLBI NIH HHS/United States ; CAPMC/ CIHR/Canada ; CA87969/CA/NCI NIH HHS/United States ; UM1 CA182934/CA/NCI NIH HHS/United States ; N01 PC067008/PC/NCI NIH HHS/United States ; HHSN268201100003C/WH/WHI NIH HHS/United States ; CA49449/CA/NCI NIH HHS/United States ; R01CA154643/CA/NCI NIH HHS/United States ; P30 ES000260/ES/NIEHS NIH HHS/United States ; P30 CA008748/CA/NCI NIH HHS/United States ; R01 CA129539/CA/NCI NIH HHS/United States ; R25 CA098566/CA/NCI NIH HHS/United States ; U58 DP000807/DP/NCCDPHP CDC HHS/United States ; N01-PC-67009/PC/NCI NIH HHS/United States ; CA149445/CA/NCI NIH HHS/United States ; R01 CA154643/CA/NCI NIH HHS/United States ; R01 CA062006/CA/NCI NIH HHS/United States ; N01 PC065064/PC/NCI NIH HHS/United States ; UL1 TR000135/TR/NCATS NIH HHS/United States ; HHSN271201100004C/AG/NIA NIH HHS/United States ; R01 CA098661/CA/NCI NIH HHS/United States ; R01CA1046282/CA/NCI NIH HHS/United States ; HHSN268201100002C/WH/WHI NIH HHS/United States ; P30 CA015083/CA/NCI NIH HHS/United States ; R01 CA092153/CA/NCI NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; UL1 TR000142/TR/NCATS NIH HHS/United States ; ImNIH/Intramural NIH HHS/United States ; 5R01 CA69669-02/CA/NCI NIH HHS/United States ; HHSN261201000035C/PC/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; P30 CA033572/CA/NCI NIH HHS/United States ; P50 CA097274/CA/NCI NIH HHS/United States ; R01 CA049449/CA/NCI NIH HHS/United States ; HHSN268201100002I/HL/NHLBI NIH HHS/United States ; P30 CA016359/CA/NCI NIH HHS/United States ; N01CO12400/CA/NCI NIH HHS/United States ; N01 CN045165/CN/NCI NIH HHS/United States ; U01 CA049449/CA/NCI NIH HHS/United States ; R01 CA149445/CA/NCI NIH HHS/United States ; #1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; P50 CA97274/CA/NCI NIH HHS/United States ; HHSN268201100001C/WH/WHI NIH HHS/United States ; HHSN268201100004C/WH/WHI NIH HHS/United States ; ES000260/ES/NIEHS NIH HHS/United States
• Volume:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:31ed9e165c17bb8e01d31fe69edc68da13bd3104092c7589c0eb8ce0af3022c5
• Download URL:
  https://stacks.cdc.gov/view/cdc/30224/cdc_30224_DS1.pdf
• File Type:
  [PDF - 518.47 KB ]