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A genome-wide association study of marginal zone lymphoma shows association to the HLA region
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January 08 2015
Source: Nat Commun. 6:5751
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Alternative Title:Nat Commun
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Description:Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
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Pubmed ID:25569183
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Pubmed Central ID:PMC4287989
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