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State-dependent architecture of thalamic reticular sub-networks
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    Behavioral state is known to influence interactions between thalamus and cortex, which are important for sensation, action, and cognition. The thalamic reticular nucleus (TRN) is hypothesized to regulate thalamo-cortical interactions, but the underlying functional architecture of this process and its state dependence are unknown. By combining the first TRN ensemble recording with psychophysics and connectivity-based optogenetic tagging, we found reticular circuits to be composed of distinct subnetworks. While activity of limbic-projecting TRN neurons positively correlates with arousal, sensory-projecting neurons participate in spindles and show elevated synchrony by slow waves during sleep. Sensory-projecting neurons are suppressed by attentional states, demonstrating that their gating of thalamo-cortical interactions is matched to behavioral state. Bidirectional manipulation of attentional performance was achieved through subnetwork-specific optogenetic stimulation. Together, our findings provide evidence for differential inhibition of thalamic nuclei across brain states, where the TRN separately controls external sensory and internal limbic processing facilitating normal cognitive function. PAPERFLICK:

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    DP1 MH103908/MH/NIMH NIH HHS/United States
    DP1MH103908/DP/NCCDPHP CDC HHS/United States
    K99 NS 078115/NS/NINDS NIH HHS/United States
    K99 NS078115/NS/NINDS NIH HHS/United States
    R00 NS078115/NS/NINDS NIH HHS/United States
    R01 GM104948/GM/NIGMS NIH HHS/United States
    R01 MH061976/MH/NIMH NIH HHS/United States
    R01 NS077986/NS/NINDS NIH HHS/United States
    R01-MH061976/MH/NIMH NIH HHS/United States
    R01MH057414/MH/NIMH NIH HHS/United States
    R01MH101209/MH/NIMH NIH HHS/United States
    R01NS077986/NS/NINDS NIH HHS/United States
    TR01-GM10498/GM/NIGMS NIH HHS/United States
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