Peroxidase-mediated Biodegradation of Carbon Nanotubes in vitro and in vivo

Kotchey, Gregg P.; Zhao, Yong; Kagan, Valerian E.; Star, Alexander

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Peroxidase-mediated Biodegradation of Carbon Nanotubes in vitro and in vivo

Supporting Files

July 12 2013
By Kotchey, Gregg P. ; Zhao, Yong ; Kagan, Valerian E.
Available in CDC Stacks on 2014-12-01T00:00:00Z

File Language:

English

Details

Alternative Title:

Adv Drug Deliv Rev
Personal Author:

Kotchey, Gregg P. ; Zhao, Yong ; Kagan, Valerian E. ; Star, Alexander
Description:

As a result of their unique electronic, optical, and mechanical properties, carbon nanotubes (CNTs) have been implemented in therapeutic and imaging applications. In an idealized situation, CNTs would be disposed of after they transport their theranostic payloads. Biodegradation represents an attractive pathway for the elimination of CNT carriers post-delivery and may be integral in catalyzing the release of the cargo from the delivery vehicle. Accordingly, recent research efforts have focused on peroxidase-driven biodegradation of CNTs. In this review, we not only summarize recent efforts to biodegrade CNTs in the test tube, in vitro, and in vivo, but also attempt to explore the fundamental parameters underlying degradation. Encouraged by the in vivo results obtained to date, we envision a future, where carbon-based nano-containers, which are specifically designed to target organs/cells, deliver their cargo, and biodegrade via peroxidase-driven mechanism, will represent an attractive therapeutic delivery option in nanomedicine.
Subjects:
Source:

Adv Drug Deliv Rev. 2013; 65(15):1921-1932
Pubmed ID:

23856412
Pubmed Central ID:

PMC3855904
Document Type:

Journal Article
Funding:

R01 OH008282/OH/NIOSH CDC HHS/United States ; U19 AI068021/AI/NIAID NIH HHS/United States ; R01ES019304/ES/NIEHS NIH HHS/United States ; U19AI068021/AI/NIAID NIH HHS/United States ; OH008282/OH/NIOSH CDC HHS/United States ; R01 ES019304/ES/NIEHS NIH HHS/United States
Volume:

65
Issue:

15
Download URL:

https://stacks.cdc.gov/view/cdc/29796/cdc_29796_DS1.pdf
File Type:

[PDF - 1.12 MB]
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:3bb8551893edf363467b982b39e65c0c7068aa3b94e94e7133357dc00ee6493d

File Language:

English

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