Peroxidase-mediated biodegradation of carbon nanotubes in vitro and in vivo

Details

• Personal Author:
  Kagan VE ; Kotchey GP ; Star A ; Zhao Y
• Description:
  As a result of their unique electronic, optical, and mechanical properties, carbon nanotubes (CNTs) have been implemented in therapeutic and imaging applications. In an idealized situation, CNTs would be disposed of after they transport their theranostic payloads. Biodegradation represents an attractive pathway for the elimination of CNT carriers post-delivery and may be integral in catalyzing the release of the cargo from the delivery vehicle. Accordingly, recent research efforts have focused on peroxidase-driven biodegradation of CNTs. In this review, we not only summarize recent efforts to biodegrade CNTs in the test tube, in vitro, and in vivo, but also attempt to explore the fundamental parameters underlying degradation. Encouraged by the in vivo results obtained to date, we envision a future, where carbon-based nano-containers, which are specifically designed to target organs/cells, deliver their cargo, and biodegrade via peroxidase-driven mechanism, will represent an attractive therapeutic delivery option in nanomedicine. [Description provided by NIOSH]
• Subjects:
  Animals Energy Metabolism Lung Men Nervous System Occupational Health Respiratory System Safety Women
• Keywords:
  Author Keywords: Biodegradation Brain-function Carbon Nanotubes Drug Delivery Drugs Graphene Humans Metabolism Nanoparticles Nanotechnology Peroxidases

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• ISSN:
  0169-409X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  65
• Issue:
  15
• NIOSHTIC Number:
  nn:20044810
• Citation:
  Adv Drug Deliv Rev 2013 Dec; 65(15):1921-1932
• Contact Point Address:
  Alexander Star, Department of Chemistry, University of Pittsburgh, 4200 Fifth Avenue, Pittsburgh, PA, 15260
• Email:
  astar@pitt.edu
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Advanced Drug Delivery Reviews
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b90db3f4915536fd88508e8f795cf073a0808c988b2561ab8cb81ae8716028a543f9019edfdde86a9c7352e7070ad619a2e94218bcdd42152e9c6fabc2f02afa
• Download URL:
  https://stacks.cdc.gov/view/cdc/200434/cdc_200434_DS1.pdf
• File Type:
  [PDF - 1.65 MB ]